Use the following zoom and pan buttons to control the image that follows them
Tab through the images or use the previous or next buttons to navigate each product image
or
Offers
Use previous and next buttons to navigate the slides of the %1 Product Carousel
Earn points on this purchase.
Highlights
Summary
DERMA E's Anti-Wrinkle Renewal Cream delivers targeted wrinkle correction with weightless hydration. Derm-recommended Retinol works synergistically with Bakuchiol to refine texture and visibly soften fine lines, while Vitamin E and Panthenol support the skin barrier and boost skin’s resilience.
Benefits
- Helps visibly reduce the look of fine lines and wrinkles
- Nourishes and smooths skin for a healthier-looking complexion
- Soothes and supports skin barrier health
- Provides lightweight, all-day hydration
Key Ingredients
- RETINOL: #1 dermatologist-recommended ingredient to reduce the appearance of fine lines and wrinkles†
- PANTHENOL (PRO-VITAMIN B5): a moisture-binding ingredient that strengthens the skin barrier and improves smoothness
- BAKUCHIOL: a gentle, plant-based retinol alternative that helps smooth texture and reduces the look of lines
- VITAMIN E: a nourishing antioxidant that helps protect skin from dryness and leaves skin soft and supple
- ALLANTOIN: a soothing skin protectant that helps keep skin smooth and calm
- †Based on an internal survey of 35 dermatologists.
Research Results
- 97% saw reduced fine lines and wrinkles †
- † Results based on single use independent clinical study after 8 weeks using the Anti-Wrinkle Collection (Cleanser, Oil, Night Treatment, Smoothing Eye Cream, and Renewal Cream)
Item 2556321
Apply onto clean face and neck. Use in the evening.
Tip: Be sure to apply ample SPF in the morning to keep skin protected!
Purified Water, Carthamus Tinctorius (Safflower) Seed Oil, Stearic Acid (Vegetable Derived), Glycerin (Vegetable Derived), Glyceryl Stearate SE, Cetyl Alcohol (Plant Derived), Microcrystalline Cellulose (Plant Derived), Cellulose Gum (Plant Derived), Persea Gratissima (Avocado) Oil, Sesamum Indicum (Sesame) Seed Oil, Helianthus Annuus (Sunflower) Seed Oil, Bakuchiol, Retinol, Panthenol (Provitamin B5), Tocopheryl Acetate (Vitamin E), Allantoin, Phenoxyethanol, Ethylhexylglycerin, Natural Fragrance Oils.
Similar items for you
12 items
Use previous and next buttons to navigate the slides of the Similar items for you Product Carousel
We think you'll like
12 items
Use previous and next buttons to navigate the slides of the We think you'll like Product Carousel
Sponsored products
12 items
Use previous and next buttons to navigate the slides of the Sponsored products Product Carousel
Reviews
Review Snapshot
by PowerReviews
Ratings Distribution
Best For
Describe Yourself
Skin Type
Most Helpful Positive Review
If you have tough skin: 10/10!!!
Im 24, 1/2 Asian, 1/2 white, I have very combination to dry skin, and pretty tolerant skin with Minimal breakouts. So take my review with a grab of salt if you have sensitive or difficult, acne prone skin. I am IN LOVE with this product. I love that it is truly effective on my face. Im pretty inco...
Most Helpful Critical Review
Formula is a little greasy
I found this formula very greasy for my face and started to breakout with acne after using. I don't typically have acne, maybe the occasional pimple at worst. However, I now use it as a hand cream and it feels luxurious when used as a hand cream. I bought this cream as an alternative to R&F Redefine...
271 results
I love this stuff
Reviewed at

I've been buying this for years. It feels so nourishing putting it on after a shower. Pharmica in Berkeley closed, and I don't know where to buy it now!
Burned face
Reviewed at

Great ingredients till you get to phenoxyethanol. Returning. Couldn't figure why this caused a burning sensation. Thst is one of the effects. Please take it out.
Works amazingly well on my skin
This works very well on my dry skin. At 57 yrs old, I've tried countless face creams/ moisturizers, never using up a product to its entirety, then I'm off trying another product. This is only the 2nd face product that I've used up to the bottom of the jar. I use it morning and night. It takes a while to be absorbed by my skin so I only use small amount in the morning. yes, I wear sunscreen & makeup over it. At night, I really slather it on my face and neck. My skin feels and looks well- hydrated, soft in the morning. Yes, I strayed at some point and used a different moisturizer for a little over month. When I used this Derma e Renewal Cream again, within 2 days, my skin looked happy! Seriously, I couldn't help looking at my skin in the sun visor mirror while I was driving! Yes, I'm ordering again when I finish writing this review.
I won't return it but I won't buy it again.
Verified Buyer
Reviewed at

Once the jar is open retinol is exposed. However, I've been using it more for other areas and it leaves my body smooth. I do not use this on my face I use a retinol encased properly.
Good One
Verified Buyer
Reviewed at

Very thick.
Questions
Q&A
Showing 5 out of 6 Questions
- Q
Does this have any peptides in it?
- Asked by Lisa
- Official Answer By DERMA E - Brand EngageIf you're looking for peptides, we recommend our Advanced Peptides and Flora-Collagen line!Was this answer helpful to you
- Q
Is this used as a moisturizer, or should I still follow it up with my normal daily moisturizer?
- Asked by Cris
- Official Answer By DERMA E - Brand EngageThis is to be used as a moisturizer.Was this answer helpful to you
- Q
What is the retinol percentage?
- Asked by C
- Official Answer By DERMA E - Brand EngageThank you for your interest in our ingredients. While we don't disclose the exact percentage of retinol this formula, I can tell you that it is always formulated at the concentration recommended for maximum results without irritation. Beyond that, it’s good to know that the percentage of an ingredient in a formula is just one part of the story. When designing each formula, DERMA E carefully considers the product’s effectiveness, natural content, pH balance, gentleness and safety.Was this answer helpful to you
- Q
Does this product come in a box?
- Asked by Jam
- Official Answer By DERMA E - Brand EngageThis product is not packaged in a box.Was this answer helpful to you
- Q
I'm a little confused, the picture of the container doesn't have the word retinol in it nor did I see any forms of retinol in the ingredient listing. Why is the title of this product page have the word retinol in it?
- Asked by michelle
- Official Answer By DERMA E - Brand EngageHere are the ingredients, including retinol (the 7th to last ingredient): "Purified Water, Carthamus Tinctorius (Safflower) Seed Oil, Stearic Acid (Vegetable Derived), Glycerin (Vegetable Derived), Glyceryl Stearate SE, Cetyl Alcohol (Plant Derived), Microcrystalline Cellulose (Plant Derived), Cellulose Gum (Plant Derived), Persea Gratissima (Avocado) Oil, Sesamum Indicum (Sesame) Seed Oil, Helianthus Annuus (Sunflower) Seed Oil, Bakuchiol, Retinol, Panthenol (Provitamin B5), Tocopheryl Acetate (Vitamin E), Allantoin, Phenoxyethanol, Ethylhexylglycerin, Natural Fragrance Oils."Was this answer helpful to you