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Highlights
Summary
This cutting-edge gel-serum specifically targets acne-causing C. acnes bacteria with the patented CUT-02™ enzyme, clearing breakouts & preventing future acne without disrupting your skin’s beneficial microbiome & without the harsh side effects of conventional acne treatments.
Benefits
- Meaningfully reduces acne symptoms without harsh side effects
- Specifically targets acne-causing C. acnes bacteria
- Preserves the skin’s beneficial bacteria and strengthens the barrier
- Lightweight gel-serum penetrates pores to control acne blemishes
- Treats all acne types, including cystic and hormonal
- Helps prevent new acne blemishes from forming
- Evens skin tone and reduces redness and oiliness
- Minimizes the appearance of pores and comedones
- Restores the skin’s protective microbiome
- Dermatologist approved, hypoallergenic, and non-comedogenic
- Safe for eye area and safe for sensitive skin
Key Ingredients
- The patented CUT-02™ enzyme strategically targets and kills acne-causing C. acnes bacteria, leaving the rest of the skin’s beneficial bacteria unharmed
- .5% salicylic acid gently exfoliates inside the pore to dissolve excess oil and dead skin cells, helping to clear breakouts and prevent new ones from forming
- Pro-Vitamin B5 reduces visible redness, adds weightless hydration, and helps replenish the skin barrier
- Antioxidant-rich centella asiatica helps to calm irritation and strengthen the skin’s naturally protective barrier
Research Results
- 99.9% of C. acnes bacteria killed within 1 hour without harming beneficial bacteria based on in vitro data of the CUT-02 enzyme
- An 8 week clinical trial was conducted with 19 adults with very mild to severe acne:
- 93% of people saw improvement in acne symptoms after 2 weeks
- 89% said their skin had less redness
- 95% said it was non-irritating
Item 77009814
*Start with a once-daily application in the evening. *Cleanse skin with Hypothesis Daily Acne Cleanser, then apply Acne Precision Serum. *Once the Acne Precision Serum has fully absorbed into the skin, apply a moisturizer as needed. *Leave on overnight. *Increase to twice daily application (morning and evening) if well-tolerated. *If you use other serums or treatments in your regimen, apply after the Daily Acne Cleanser and before the Acne Precision Serum. *Note: As products with salicylic acid can increase your skin’s sun sensitivity, use an SPF during the day.
*Active Ingredient: Salicylic Acid 0.5% *Inactive Ingredients: Water/Aqua/Eau, Betaine, Methylpropanediol, Glycerin, Panthenol, Hydroxyethylpiperazine Ethane Sulfonic Acid, Sodium Chloride, Arginine HCl, Methionine, Hydroxypropyl Methylcellulose, Centella Asiatica Herb Extract, Caprylhydroxamic Acid, 1,2-Hexanediol, Propanediol, Sodium Hydroxide, Hydrochloric Acid, sr-(Caudoviricetes Polypeptide-1 Depeptide-81 Cutibacterium Acnes Polypeptide-1 Pentapeptide-124 Dipeptide-19 Hexapeptide-40)
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Reviews
Review Snapshot
by PowerReviews
Ratings Distribution
19 results
Effective and didn't blast the skin
I got this for my daughter who has been dealing with acne, and who had no luck with standard salicylic acid products like pads and washes. This was very effective and I feel much better about giving her these products than benzoyl peroxide which is drying, irritating, and has issues with contaminants or breakdown products.
The most gentle salicylic acid serum
I used this serum nightly for 3 weeks, then began alternating nights with azelaic acid to help with dark spots. The serum was really gentle on my sensitive skin and didn't cause any stinging, which was a huge surprise because most acids do make my face react a little bit. I am still getting breakouts a few times a month but they seem to be clearing faster than before which is an improvement! The only thing I don't love about this serum is the smell—I know it's fragrance free (which is great!) but because there isn't any added fragrance, it kind of smells like french fry oil? Not the best lol, but it dissipates fairly quickly.
Amazing Acne Treatment Serum!
Super easy to use because it’s nice and lightweight which my skin and I appreciate. After consistently using everyday, I noticed my skin texture looking more even and smooth. While treating my breakouts, reducing the amount of pimples that appeared, it also definitely reduced my post blemish redness in intensity and time on my skin.
Helps prevent new break-outs
It definitely takes a few weeks but I am starting to see improvement. It is very gentle and non-drying.


Gentle and works so well!
I love this product and it will be one of my must-haves in my routine from now on. Although it has a bit of a weird smell, the cleanser helps to reduce that and I would rather it smell weird than have questionable ingredients. My acne was much less frequent and my pores were minimized over time. The balance of my skin also improved, with less oiliness, dry patches and irritation. When I did get acne around my period it resolved many times overnight. I still think retinol and retinoids have their place so pigmentation if there is a pimple that comes up, but overall I love this product and think it worked much better than expected.