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Summary
Highlights
Clinique Smart Night Clinical MD Treatment Retinol Serum is a skin-repairing night treatment that jumpstarts the anti-aging process with retinol plus hydration.
Benefits
- All Skin Types.
- Powered by 0.3% retinol, this creamy formula sinks in to help speed up cell turnover.
- Visibly reduces fine lines and wrinkles.
- Skin tone looks more even, radiant.
- Pores look minimized.
- Delivers instant and lasting hydration, which helps comfort skin and offset dryness sometimes associated with retinol.*
- *Tolerance to retinol varies by person.
- What you should know about retinol:
- Retinol is an extremely effective and powerful anti-aging ingredient. You may experience mild redness, a warm, tingling sensation, or flaking (skin exfoliation). These conditions are normal, temporary indications that the formula is working.
- If you experience increased discomfort when using this product, revert to once every other night until skin adjusts. This adjustment can take up to 4 weeks.
- First time users and those with drier skin types may want to use this product every other night for more than 2 weeks to give skin additional time to adjust.
- For added comfort, use a mild cleanser and layer an additional moisturizer over this product.
- Limit sun exposure in general. Be sure to apply a sunscreen of SPF15 or higher during the day while using this product, and one week after stopping use of it. Note that extreme weather conditions such as wind or cold may be more irritating, so take the proper precautions to protect your face.
- Paraben-free. Phthalate-free.
- No Denatured alcohol. No Synthetic colors.
- SLS-free. SLES-free. Sulfate-free.
- Dermatologist tested.
- Allergy tested. Fragrance-free.
Key Ingredients
- Retinol (0.3%): A pure form of Vitamin A, it's an effective anti-aging ingredient known to help visibly reduce lines and wrinkles, minimize the appearance of pores, and smooth and refine texture.
- Youth-Boosting Blend: Helps skin look smoother. Includes acetyl hexapeptide-8, niacinamide, sigesbeckia extract, and ascorbic acid.
- Comforting Hydrator Blend: Helps infuse skin with hydration. Includes hyaluronic acid, mango seed butter, wheat and barley extract, coffee seed oil, squalane, and vitamin E.
Research Results
- Clinical Testing:
- Restores radiance with 1 use.
- Minimizes the appearance of pores in 7 days.
- Skin feels smoother in 28 days/4 weeks.
- Improves evenness of skin tone in 8 weeks.
- Retexturizes skin in 12 weeks.
- Provides instant and lasting hydration.
- With continued use, visibly reduces lines and wrinkles.
Item 2572793
Apply pea size amount (0.25g) of retinol at night. Avoid eye area. Tip: For first two weeks, use every other night, then nightly. Use sunscreen and limit sun exposure while using and the week after. Do not use with other retinol products, such as Clinique Fresh Pressed Overnight Booster with Pure Vitamin A (Retinol).
To help optimize the results of retinol, we suggest using as part of a regimen with other anti-aging products, such as:
- In AM: Clinique Smart Custom-Repair Serum + Clinique Smart SPF 15 Custom-Repair Moisturizer
- In PM: Clinique Smart Custom-Repair Serum + Clinique Smart Night Retinol + Clinique Smart Clinical MD Resculpt or Revolumize or Clinique Smart Night Custom-Repair Moisturizer (for added comfort if needed).
Water\Aqua\Eau, Caprylic/Capric Triglyceride, PPG-15 Stearyl Ether, C12-20 Acid PEG-8 Ester, Glycerin, Niacinamide, Phenyl Trimethicone, Caprylic/Capric/Myristic/Stearic Triglyceride, Algae Extract, Dimethicone, Hydroxyethyl Urea, Cetyl Alcohol, Retinol, Sigesbeckia Orientalis (St. Paul'S Wort) Extract, Mangifera Indica (Mango) Seed Butter, Coffea Arabica (Coffee) Seed Oil, Sodium Hyaluronate, Caffeine, Ascorbic Acid, Urea, Butylene Glycol, Squalane, Trehalose, Triticum Vulgare (Wheat) Germ Extract, Tocopheryl Acetate, PEG-100 Stearate, Linoleic Acid, Glyceryl Stearate, Hordeum Vulgare (Barley) Extract\Extrait D'Orge, Acetyl Hexapeptide-8, Sorbitol, Potassium Cetyl Phosphate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tocopherol, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Behenyl Alcohol, Sodium Pca, Sodium Hydroxide, Caprylyl Glycol, Carbomer, Triacetin, Polyquaternium-51, Xanthan Gum, BHT, Disodium EDTA, Sodium Metabisulfite, Chlorphenesin, Potassium Sorbate, Phenoxyethanol.
Please be aware that ingredient lists may change or vary from time to time. Please refer to the ingredient list on the product package you receive for the most up to date list of ingredients.
This brand is excluded from most Ulta Beauty coupons.
Free gift with purchase
Free gift with purchase
Online only receive a complimentary Even Better Clinical Vitamin Makeup Foundation sample with Clinique purchase (valid thru 8/2/25 on shipped purchases only. Full or partial pickup or same day delivery purchases do not qualify. While quantities last)
Free gift with purchase
Online only receive a complimentary cleansing balm with $50 Clinique purchase (valid thru 8/2/25 on shipped purchases only. Full or partial pickup or same day delivery purchases do not qualify. While quantities last)
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Questions
Ask a QuestionQ&A
Showing 15 out of 10 Questions
- Q
What percent is this product
- Asked by Mary
- Official Answer By Clinique USWe're glad you asked! Clinique Smart Night Clinical MD Multi-Dimensional Repair Treatment Retinol, which contains Retinol (0.3%), a pure form of Vitamin A as an effective anti-aging ingredient known to help visibly reduce lines and wrinkles, minimize the appearance of pores, and smooth and refine texture. Retinol is an extremely effective and powerful anti-aging ingredient. We do not recommend using two retinol products together. Be sure you are limiting sun exposure while using, and for at least one week after. Visit our store, and a Beauty Associate will offer personalized application tips. We'd love to hear your feedback!Was this answer helpful to you
- Q
Do you have a night cream moisturizer
- Asked by T
- Official Answer By Clinique USWe are so happy you asked! We have a great moisturizer for nighttime use that works perfectly with this serum. Clinique's Smart Clinical Repair Wrinkle Correcting Cream visibly repairs lines and wrinkles, hydrates and strengthens. Visit us in-store at your nearest Ulta to experience this moisturizer!Was this answer helpful to you
- Q
You recommend using clinique smart night moisturizer after using this product, however that is no longer available on your website. Will you be bringing this back? I was told to use this in place of the moisturizer at night. This is frustrating.
- Asked by Patty
- Official Answer By Clinique USThanks for asking, we never want our fans frustrated! Clinique Smart Night Clinical MD Multi-Dimensional Repair Treatment Retinol Serum, as a serum, should be followed by your favorite Clinique moisturizer after. We like Clinique Smart Clinical Repair Wrinkle Correcting Cream (or Rich Cream for those that need deep hydration). This moisturizer may be used in place of the retired Clinique Smart Night Custom-Repair Moisturizer. When using the serum, for the first two weeks, only use it every other night, then nightly. Remember to always use sunscreen and limit sun exposure while using and the week after.Was this answer helpful to you
- Q
Do I moisturize before or after?
- Asked by donkey mom
- Official Answer By Clinique USWe're so glad you asked! Apply your moisturizer after Clinique Smart Night Clinical MD Multidimensional Repair Treatment Retinol. We recommend Clinique Smart Clinical MD Multi-Dimensional Age Transformer Resculpt or Revolumize or Clinique Smart Night Custom-Repair Moisturizer. Enjoy!Was this answer helpful to you
- Q
Can I use this with the night time turn around cream?
- Asked by Laura
- Official Answer By Clinique USThank you for your question. We recommend using Clinique Smart Nigth Clinical MD Multi-Dimensional Repair Treatment Retinol with Clinique Smart Night Custom-Repair Moisturizer, which helps skin attract and retain moisture and gives skin an extra boost of repair while you sleep. We can't wait to hear what you think! Was this answer helpful to you
- Q
Is it safe to continue to use this product if you experience the mild redness since that means it is working?
- Asked by KG
- Official Answer By Clinique USThanks for reaching out. Clinique is committed to selling safe products - all of our ingredients undergo a comprehensive safety review and evaluation, and our products are safe for their intended use. Retinol is an extremely effective and powerful anti-aging ingredient. You may experience mild redness, a warm, tingling sensation, or skin exfoliation. These conditions are normal, temporary indications that the formula is working. If you experience increased discomfort when using Clinique Smart Night Clinical MD Multi-Dimensional Repair Treatment Retinol, revert to once every other night until skin adjusts. This adjustment can take up to 4 weeks. Be sure to apply a sunscreen of SPF15 or higher during the day while using and limit sun exposure in general. Was this answer helpful to you
- Q
Can this be used with Laser Focus night cream?
- Asked by DianeS
- Official Answer By Clinique USWe're so glad you asked! Use with Repairwear Laser Focus Night Line Smoothing Cream in the PM for added comfort and to help optimize the results of retinol. Make sure to use sun protection in the morning and limit sun exposure for the first 3 weeks of use. Was this answer helpful to you
- Q
In what order do I use the product thank you
- Asked by Gladys
- Official Answer By Clinique USWe are happy to help! For best results we recommend using your Clinique 3 Step Skincare routine, any treatment serums and then following with your Clinique Smart Night Clinical MD Multi-Dimensional Repair Treatment Retinol Serum. We do recommend limiting sun exposure while using Clinique Smart Night Clinical MD Multi-Dimensional Repair Treatment Retinol. Be sure to apply a sunscreen of SPF 15 or higher during the day while using and one week after stopping use of Clinique Smart Night Clinical MD Multi-Dimensional Repair Treatment Retinol. Thank you for your question. Was this answer helpful to you
- Q
My greatest area of concern is my neck. I also have sensitive, dry skin. Can this be used on the neck, or is it mainly for the face? If not for the neck, what would you recommend for the neck area that is gentle yet effective for firming and reducing lines and wrinkles.
- Asked by Clinique User
- Official Answer By Clinique USWe are happy to help. Guests love the instant-tightening feel of the gel-cream Clinique Smart Clinical MD Multi-Dimensional Age Transformer Resculpt. Apply to face, neck, decolletage, and/or jawline where you want to create visibly firmer, lifted and contoured skin, while also visibly correcting lines and wrinkles, dullness and uneven tone. Enjoy!Was this answer helpful to you
- Q
Would I apply this before or after the smart repair serums ? Also it says to avoid eye area but does that mean the lid only or can I use it on the "crows feet" area or under the eye ? Thank you
- Asked by Joni
- Official Answer By Clinique USThank you for asking. For best results we recommend first applying Clinique Smart Custom-Repair Serum then following with Clinique Smart Night Clinical MD Multi-Dimensional Repair Treatment Retinol Serum. While Clinique Smart Night Clinical MD Multi-Dimensional Repair Treatment Retinol Serum is formulated for the face, we recommend using Clinique Smart Custom-Repair Eye Treatment to help with visible signs of aging in the area and/ or Clinique Repairwear Laser Focus Wrinkle Correcting Eye Cream as a potent eye cream with visible wrinkle-reducing power. Enjoy!Was this answer helpful to you
- Q
Is it safe to continue to use this product if you experience the mild redness since that means it is working?
- Asked by KG
- Official Answer By Clinique USThanks for reaching out. Clinique is committed to selling safe products - all of our ingredients undergo a comprehensive safety review and evaluation, and our products are safe for their intended use. Retinol is an extremely effective and powerful anti-aging ingredient. You may experience mild redness, a warm, tingling sensation, or skin exfoliation. These conditions are normal, temporary indications that the formula is working. If you experience increased discomfort when using Clinique Smart Night Clinical MD Multi-Dimensional Repair Treatment Retinol, revert to once every other night until skin adjusts. This adjustment can take up to 4 weeks. Be sure to apply a sunscreen of SPF15 or higher during the day while using and limit sun exposure in general. Was this answer helpful to you
- Q
Can this be used with Laser Focus night cream?
- Asked by DianeS
- Official Answer By Clinique USWe're so glad you asked! Use with Repairwear Laser Focus Night Line Smoothing Cream in the PM for added comfort and to help optimize the results of retinol. Make sure to use sun protection in the morning and limit sun exposure for the first 3 weeks of use. Was this answer helpful to you
- Q
In what order do I use the product thank you
- Asked by Gladys
- Official Answer By Clinique USWe are happy to help! For best results we recommend using your Clinique 3 Step Skincare routine, any treatment serums and then following with your Clinique Smart Night Clinical MD Multi-Dimensional Repair Treatment Retinol Serum. We do recommend limiting sun exposure while using Clinique Smart Night Clinical MD Multi-Dimensional Repair Treatment Retinol. Be sure to apply a sunscreen of SPF 15 or higher during the day while using and one week after stopping use of Clinique Smart Night Clinical MD Multi-Dimensional Repair Treatment Retinol. Thank you for your question. Was this answer helpful to you
- Q
My greatest area of concern is my neck. I also have sensitive, dry skin. Can this be used on the neck, or is it mainly for the face? If not for the neck, what would you recommend for the neck area that is gentle yet effective for firming and reducing lines and wrinkles.
- Asked by Clinique User
- Official Answer By Clinique USWe are happy to help. Guests love the instant-tightening feel of the gel-cream Clinique Smart Clinical MD Multi-Dimensional Age Transformer Resculpt. Apply to face, neck, decolletage, and/or jawline where you want to create visibly firmer, lifted and contoured skin, while also visibly correcting lines and wrinkles, dullness and uneven tone. Enjoy!Was this answer helpful to you
- Q
Would I apply this before or after the smart repair serums ? Also it says to avoid eye area but does that mean the lid only or can I use it on the "crows feet" area or under the eye ? Thank you
- Asked by Joni
- Official Answer By Clinique USThank you for asking. For best results we recommend first applying Clinique Smart Custom-Repair Serum then following with Clinique Smart Night Clinical MD Multi-Dimensional Repair Treatment Retinol Serum. While Clinique Smart Night Clinical MD Multi-Dimensional Repair Treatment Retinol Serum is formulated for the face, we recommend using Clinique Smart Custom-Repair Eye Treatment to help with visible signs of aging in the area and/ or Clinique Repairwear Laser Focus Wrinkle Correcting Eye Cream as a potent eye cream with visible wrinkle-reducing power. Enjoy!Was this answer helpful to you
Reviews
Write A REVIEWReview Snapshot
by PowerReviews
Ratings Distribution
Skin Type
Most Helpful Positive Review
Excellent!
The negative reviews of this product surprise me and that some are saying that the directions are not clear. Any time one uses a Retinol product, you HAVE to apply a moisturizer over it. If you don't, you will end up with red, dry, painful skin. The directions on the pkg insert as well as here under...
Most Helpful Critical Review
Too intense for my dry and sensitive skin
I used this product as directed and had to discontinue it before I even made it out of the two week period where you only use it every other day. As a disclaimer I wasn't even going outside (thanks COVID) so it wasn't like I got a bunch of sun and messed myself up. I really did use it as directed. ...
111 results
Disappointed - New Formula?
Verified Reviewer
Reviewed at
I hate to leave this review because I love Clinique. And this product, until it mysteriously went out of stock for 6 months and now, newly available again, it looks different (stark white cream vs original tan/beige color) and completely dries my skin out. I'm so sad because my skin is too dry/sensitive for most retinol products and this one was amazing. Seems like they want to replace with the new retinol serum (even stronger - tried it and had major redness & flaking) and night cream duo but we don't want or need 2 products in place of 1. Please change it back!
Best product ever for aging skin
Verified Reviewer
Reviewed at
This is a fantastic product. After using it for more than a year, a very good friend told me that it looked like I had had work done! It made my skin look visibly younger. Please, please do not discontinue this. While it has been unavailable, I have been using all of the other anti-aging products that Clinique offers, and none of them compare to this product.
Good Product but....
Verified Reviewer
Reviewed at
The product makes my skin very smooth and clear but the price......pricey...!!! Why so expensive???
Was great. What happened?
Verified Reviewer
Reviewed at
Clinique has a bad habit of making a good product then discontinuing it when they make another product to substitute for it in smaller quantities and higher prices. The formulation of this was great when it was first introduced. Not sure what changed. I used to see the dark spots just falling off, but that hasn't been the case as of late. It still makes my skin dewy and soft, but something happened and my skin shows it. Now, there's a serum. Much smaller. Much more expensive. Not as forgiving of a formula. I keep trying to give this company a chance, but the whole point is a skin care routine is CONSISTENCY. I'll find a more reliable brand. I just can't do another purge stage while my skin gets used to another product that'll just get discontinued in a year or so.
Magic in a tube
Verified Reviewer
Reviewed at
This stuff is a miracle. My skin hasn't looked this great in 20 years! I'm a man with dry, very sensitive skin and about to turn 50. I tried prescription strength retinol creams - which worked but were expensive, difficult to get, and caused irritation if used too much. This...WOW. Same results, if not a little better than the prescriptions. People have commented and I see a difference with regular use. It's part of an overall routine - but an important piece to the puzzle. When I wake up - my face looks amazing. I see less wrinkles and fine lines, my complexion is smoother, and face is more radiant. It is worth the high price and I always have a 2nd tube ready to go since it sometimes goes out of stock. It's not greasy, and it absorbs very well. I use the dark spot serum with this at night, and then use the rapid turnaround nightly moisturizer. My face looks amazing, feels great, and people in-person and on Zoom can see the difference.