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Highlights
Summary
DERMA E's Anti-Wrinkle Renewal Cream delivers targeted wrinkle correction with weightless hydration. Derm-recommended Retinol works synergistically with Bakuchiol to refine texture and visibly soften fine lines, while Vitamin E and Panthenol support the skin barrier and boost skin’s resilience.
Benefits
- Helps visibly reduce the look of fine lines and wrinkles
- Nourishes and smooths skin for a healthier-looking complexion
- Soothes and supports skin barrier health
- Provides lightweight, all-day hydration
Key Ingredients
- RETINOL: #1 dermatologist-recommended ingredient to reduce the appearance of fine lines and wrinkles†
- PANTHENOL (PRO-VITAMIN B5): a moisture-binding ingredient that strengthens the skin barrier and improves smoothness
- BAKUCHIOL: a gentle, plant-based retinol alternative that helps smooth texture and reduces the look of lines
- VITAMIN E: a nourishing antioxidant that helps protect skin from dryness and leaves skin soft and supple
- ALLANTOIN: a soothing skin protectant that helps keep skin smooth and calm
- †Based on an internal survey of 35 dermatologists.
Research Results
- 97% saw reduced fine lines and wrinkles †
- † Results based on single use independent clinical study after 8 weeks using the Anti-Wrinkle Collection (Cleanser, Oil, Night Treatment, Smoothing Eye Cream, and Renewal Cream)
Item 2556321
Apply onto clean face and neck. Use in the evening.
Tip: Be sure to apply ample SPF in the morning to keep skin protected!
Purified Water, Carthamus Tinctorius (Safflower) Seed Oil, Stearic Acid (Vegetable Derived), Glycerin (Vegetable Derived), Glyceryl Stearate SE, Cetyl Alcohol (Plant Derived), Microcrystalline Cellulose (Plant Derived), Cellulose Gum (Plant Derived), Persea Gratissima (Avocado) Oil, Sesamum Indicum (Sesame) Seed Oil, Helianthus Annuus (Sunflower) Seed Oil, Bakuchiol, Retinol, Panthenol (Provitamin B5), Tocopheryl Acetate (Vitamin E), Allantoin, Phenoxyethanol, Ethylhexylglycerin, Natural Fragrance Oils.
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Reviews
Review Snapshot
by PowerReviews
Ratings Distribution
Best For
Describe Yourself
Skin Type
Most Helpful Positive Review
If you have tough skin: 10/10!!!
Im 24, 1/2 Asian, 1/2 white, I have very combination to dry skin, and pretty tolerant skin with Minimal breakouts. So take my review with a grab of salt if you have sensitive or difficult, acne prone skin. I am IN LOVE with this product. I love that it is truly effective on my face. Im pretty inco...
Most Helpful Critical Review
Formula is a little greasy
I found this formula very greasy for my face and started to breakout with acne after using. I don't typically have acne, maybe the occasional pimple at worst. However, I now use it as a hand cream and it feels luxurious when used as a hand cream. I bought this cream as an alternative to R&F Redefine...
271 results
So far I really like this
Have been using for just a week so far but in this short time a really like it. Not greasy but very moisturizing
Great face cream
I highly recommend this product if you have oily skin, it balances out the oils and makes skin glow. It is clean beauty for sure I have sensitive skin and allergies to many products I am so happy I found this skin care line.
Excellent face and neck cream
I bought this because my normally oily, breakout prone skin was dry. I also have rosacea so its tricky to keep my skin balanced. It is fantastic. It absorbs quickly and isnt greasy. I haven't had any breakouts or rosacea flare ups. I only use it at night on my face and neck.
Does wonders in cold weather climates
Reviewed at

I wear this product year round, but I notice the most benefits in the winter where it protects me from dry and cold weather. I have acne prone skin and have not broken out while using it.
I would buy this product again.
I love how it makes my face feel.
Questions
Q&A
Showing 5 out of 6 Questions
- Q
Does this have any peptides in it?
- Asked by Lisa
- Official Answer By DERMA E - Brand EngageIf you're looking for peptides, we recommend our Advanced Peptides and Flora-Collagen line!Was this answer helpful to you
- Q
Is this used as a moisturizer, or should I still follow it up with my normal daily moisturizer?
- Asked by Cris
- Official Answer By DERMA E - Brand EngageThis is to be used as a moisturizer.Was this answer helpful to you
- Q
What is the retinol percentage?
- Asked by C
- Official Answer By DERMA E - Brand EngageThank you for your interest in our ingredients. While we don't disclose the exact percentage of retinol this formula, I can tell you that it is always formulated at the concentration recommended for maximum results without irritation. Beyond that, it’s good to know that the percentage of an ingredient in a formula is just one part of the story. When designing each formula, DERMA E carefully considers the product’s effectiveness, natural content, pH balance, gentleness and safety.Was this answer helpful to you
- Q
Does this product come in a box?
- Asked by Jam
- Official Answer By DERMA E - Brand EngageThis product is not packaged in a box.Was this answer helpful to you
- Q
I'm a little confused, the picture of the container doesn't have the word retinol in it nor did I see any forms of retinol in the ingredient listing. Why is the title of this product page have the word retinol in it?
- Asked by michelle
- Official Answer By DERMA E - Brand EngageHere are the ingredients, including retinol (the 7th to last ingredient): "Purified Water, Carthamus Tinctorius (Safflower) Seed Oil, Stearic Acid (Vegetable Derived), Glycerin (Vegetable Derived), Glyceryl Stearate SE, Cetyl Alcohol (Plant Derived), Microcrystalline Cellulose (Plant Derived), Cellulose Gum (Plant Derived), Persea Gratissima (Avocado) Oil, Sesamum Indicum (Sesame) Seed Oil, Helianthus Annuus (Sunflower) Seed Oil, Bakuchiol, Retinol, Panthenol (Provitamin B5), Tocopheryl Acetate (Vitamin E), Allantoin, Phenoxyethanol, Ethylhexylglycerin, Natural Fragrance Oils."Was this answer helpful to you