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Perricone MD Neuropeptide Deep Crease Serum
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Summary
Perricone MD's Neuropeptide Deep Crease Serum reduces the appearance of deep creases, marionette & lip lines.
Benefits
- This highly-potent, silky serum smooths the look of even the most stubborn, deep lines, wrinkles & creases around the mouth, eyes, lips & forehead, including marionette lines, frown lines, smile lines & nasolabial folds
- Over time, wrinkle depth appears shallower & the look of expression lines reduced
Key Ingredients
- Neuropeptides: Uniting Surface Cells to Fight Wrinkles
- Biomimetic Growth Factor Peptides
- Plant Stem Cells
Item 2648227
After cleansing, massage onto face & neck using a gentle upward motion. Wait until fully absorbed & follow with your favorite Perricone MD moisturizer. Use morning & evening.
If the product enters the eye, rinse with water to remove.
Water/Aqua/Eau, Niacinamide, Coconut Alkanes, Glycerin, Caprylic/Capric Triglyceride, Isodecyl Neopentanoate, Squalane, Isononyl Isononanoate, Butylene Glycol, Lactobacillus/Glycine Soybean Ferment Extract, Polyglutamic Acid, Phenoxyethanol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Chlorella Vulgaris Extract, Glyceryl Stearate Citrate, Coco-Caprylate/Caprate, Hydroxyacetophenone, Polyglyceryl-3 Stearate, Hydrolyzed Rice Protein, Sodium Hyaluronate, Propanediol, Xanthan Gum, Pullulan, Hydrogenated Lecithin, Fragrance (Parfum), Polysorbate 60, Citric Acid, Sodium Phytate, Malus Domestica Fruit Cell Culture Extract, Sorbitan Isostearate, Glyceryl Stearate, Pentylene Glycol, Carbomer, Ceteareth-25, Coco-Glucoside, Sodium Lactate, Ubiquinone, Lecithin, Sodium Benzoate, Potassium Sorbate, Caprylyl Glycol, Acetyl Hexapeptide-8, Ceteareth-6, Lactic Acid, Pterocarpus Marsupium Bark Extract, Tocopherol, Stearyl Alcohol, Acetic Acid, Ethylhexylglycerin, Palmitoyl Tripeptide-1, Sodium Hydroxide, Palmitoyl Tetrapeptide-7, Nicotiana Benthamiana Hexapeptide-40 SH-Oligopeptide-1, Nicotiana Benthamiana Octapeptide-30 SH-Oligopeptide-2, Citronellol, Hydroxycitronellal, Limonene, Linalool.
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Reviews
Review Snapshot
by PowerReviews
Ratings Distribution
Most Helpful Positive Review
Botox Alternative? For SOFTENING creases trying Pe
At 42, I'm at the point where my forehead wrinkles are becoming a permanent, prominent feature, and I'm desperately trying to avoid the injectable route! I'm looking for a serious solution that can deliver noticeable results without a trip to the dermatologist, which is why I was so excited to incor...
Most Helpful Critical Review
It's ok
Been using this product for about a week--I think it could've used a longer test time and I also don't believe that a before/after photo would do the best at demonstrating its efficacy, since skincare rarely makes a dramatic enough impact to be perceptible on camera. But all the same, if that's what...
121 results
Botox Alternative? For SOFTENING creases trying Pe
Verified Reviewer
Submitted as part of a sweepstakes entry
Reviewed at

At 42, I'm at the point where my forehead wrinkles are becoming a permanent, prominent feature, and I'm desperately trying to avoid the injectable route! I'm looking for a serious solution that can deliver noticeable results without a trip to the dermatologist, which is why I was so excited to incorporate the Perricone MD Neuropeptide Deep Crease Serum into my routine. This serum truly lives up to the "luxurious" label. It has a beautiful, thick consistency and a rich texture that feels incredibly nourishing on the skin. And honestly, the fabulous smell makes applying it a pleasure. For overall skin quality and hydration, it's a winner. My main target area is my forehead. After nearly a month of consistent use, I'm not ready to say it's a miracle worker, but I am optimistic. The deep creases may look a little softer and less harsh, which is exactly the kind of incremental progress I'm hoping for as an alternative to quick fixes. I haven't decided if it does everything it promises, but I believe this anti-aging route is worthwhile. My one major critique relates to the packaging. The serum is very thick, and unfortunately, the dropper mechanism on my bottle has been a total dud. It simply doesn't draw up the product effectively. I'm unsure whether this is a design flaw due to the serum's density or a faulty dropper, but it makes the application process needlessly difficult. Given the high price point, I expect the delivery system to be flawless. Despite the frustrating dropper, I believe the potential softening effect is real enough that I am committing to a second bottle when this one runs out (perfect timing for Ulta's holiday sales!). This serum seems like a good middle-ground to avoid both harsh forehead lines and injectables. If you are looking for a high-end, beautifully scented face serum that delivers long-term, softening results for deep creases, I recommend giving this a try, but be warned about the dropper! I'm excited to see what another month of use delivers.
Wrinkle buster!
Verified Reviewer
Submitted as part of a sweepstakes entry
Reviewed at

Love this the smell is light and nice, it's a nice thick serum but doesn't feel sticky on your face. The packaging feels and looks luxurious. The wrinkles seem less just on first application 🥰 Will continue to buy!
Love the improvement in my skin
Verified Reviewer
Submitted as part of a sweepstakes entry
Reviewed at

I have been on a mission to find the right wrinkle solution for my sensitive skin. I turned 40 this year and definitely notice that my skin has changed. Add to that my super stressful job and my forehead now has noticeable fine lines and some deeper wrinkles that I have struggled to get rid of. I have used other Perricone MD products before and really liked them, so I had high hopes for this serum. The serum comes packaged in a glass dropper bottle. It is unscented and has a silky texture. It is lightweight and blends easily, I needed very little product to cover my face and neck. The serum absorbs completely, is not greasy and worked really well under my makeup- no pilling. Having used this twice a day for almost two weeks now I definitely do notice an improvement in my fine lines and wrinkles. The deeper wrinkles look much softer and my skin has a more youthful appearance overall. I am definitely happy with the results so far!
Fine lines goodbye
Verified Reviewer
Submitted as part of a sweepstakes entry
Reviewed at

Wow is this product effective and a game changer. Safe and effective for sensitive skin conditions. Has a light scent and goes on super smooth. Is not heavy or greasy.
Can't wait for the results
Verified Reviewer
Submitted as part of a sweepstakes entry
Reviewed at

I got the Neuropeptide Deep Crease Serum by Perricone MD from Influenster in exchange for my honest opinion. This is a brand that I've heard praises from but never used, and to be honest, I'm quite excited to do so along with noticing the results Beginning with the softness and silky texture along with the subtle and beautiful scent. This product amongst its many ingredients contains Acyl-Glutathione and a Vitamin F blend.