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Summary
Hypothesis Eczema Precision Hydrogel is the first eczema treatment to address the skin’s microbiome imbalance head on: Formulated with the patented TPZ-01™ enzyme, it targets eczema-associated Staph aureus bacteria while preserving the skin’s beneficial microbes for real, lasting relief.
Benefits
- 2.5x more effective than a standard eczema treatment
- 85% reduction in eczema-associated Staph aureus bacteria on the skin
- 94% of participants reported reduced itching
- 100% of participants saw reduced eczema symptoms within 2 weeks
- First-of-its-kind formula breaks the cycle of itching and irritation so sensitive, eczema-prone skin can heal
- Microbiome-friendly hydrogel for eczema flare-ups on face and body
- Precision TPZ-01™ enzyme targets and kills harmful Staph aureus bacteria to rebalance the skin’s microbiome
- Lightweight cooling gel soothes and hydrates skin
- Dermatologist approved, hypoallergenic, and clinically tested for safety and efficacy
- Accepted by the National Eczema Association (NEA) and EWG Verified®
- Certified Microbiome-Friendly for Eczema for infants and adults by MyMicrobiome
- Based on a 2-week clinical trial of 24 adults with moderate to severe eczema comparing Hypothesis Eczema Precision Hydrogel to a product containing over-the-counter levels of colloidal oatmeal.
Key Ingredients
- The patented TPZ-01™ enzyme selectively targets and kills 99.99% of eczema-associated Staph aureus bacteria within 5 minutes while preserving beneficial microorganisms
- Colloidal oatmeal protects skin, soothes itching and calms irritation from eczema
- Pro-Vitamin B5 and Sorbitol are two potent moisture magnets that hydrate, comfort, and help replenish the skin barrier
- An antioxidant-rich amino acid complex helps support skin elasticity and improve moisture retention
Formulated Without
- Steroids
- Fragrance
- Silicones
- Phthalates
- Propylene glycol
- Lanolin
- Essential oils
- Dyes
Item 77005176
- Shake and apply to eczema-prone skin at least twice daily (morning and evening) or as often as desired.
- Let absorb into the skin for 5 minutes before layering on other skincare.
- Use as a standalone treatment or use in conjunction with the Hypothesis Precision Healing Spray for a double dose of the patented TPZ-01™ enzyme.
- Follow with Hypothesis Eczema Therapy Cream to lock in moisture.
- Active Ingredient: 0.01% Colloidal Oatmeal
- Inactive Ingredients: Water/Aqua/Eau, Sorbitol, Arginine HCl, Hydroxyethylpiperazine Ethane Sulfonic Acid, Panthenol, Sodium Chloride, Hydroxypropyl Methylcellulose, Methionine, Calcium Chloride, Methylparaben, Sodium Hydroxide, Acetyl Cysteine, sr-(Staphylococcus sp. Polypeptide-1 Dipeptide-81 Streptococcus Suis Phage Polypeptide-1 Dipeptide-19 Hexapeptide-40), Hydrochloric Acid
This brand is excluded from most Ulta Beauty coupons.
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Reviews
Review Snapshot
by PowerReviews
Ratings Distribution
63 results
Relief
Since using hypothesis products, the itching and soreness of my eczema, has decreased to the point where it is manageable. I'm very pleased to have discovered the product and am recommending it to anyone and everyone who deals with eczema. Thank you.
Hypothesis is the best eczema solution I've used.
My 6-year-old has struggled with eczema since he was a baby. For a short period, it actually seemed to self improve while he was going through OIT for a peanut allergy. Thankfully he's beaten the allergy, but once he started to eat more peanuts on a regular basis, the eczema flare-ups came back. I heard about Hypothesis through a friend and decided to give it a try. To say the results were incredible is an understatement. Within just a couple of weeks his red, itchy skin completely returned to normal...and for the first time he didn't complain at all about stinging or burning from the spray or serum. I'll always keep this on hand for future flare-ups.
Relief and repair
This is the first product in years that I've found has helped my eczema and not made it worse. These are some before and after pictures of just my hands.


Excellent products for eczema!!!
I am very impressed with these products. Truthfully, I didn't expect them to work as well as they do. But I wanted to give them a chance. I ordered the complete eczema care set and have used the products as directed now for about two weeks. I can honestly say my skin has shown major reductions in itching and redness. I couldn't be happier with results I have obtained from using these products.
Infant Eczema Success
My now 5 month old has been dealing with eczema since he was just a month old which mainly affects the cheeks of his face- causing them to be "weepy" and red. I've tried so many things (probiotics, hypochlorous spray, Manuka honey, Dead Sea salt baths.... you name it and I most likely tried it). My biggest promise was to avoid steroids and I'm glad I didn't give in. Within two weeks of consistent use this is the best his skin has looked since coming home from the hospital. I am overjoyed and grateful for this product. It's a staple in his skincare routine!

