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Summary
Hypothesis Eczema Precision Hydrogel is the first eczema treatment to address the skin’s microbiome imbalance head on: Formulated with the patented TPZ-01™ enzyme, it targets eczema-associated Staph aureus bacteria while preserving the skin’s beneficial microbes for real, lasting relief.
Benefits
- 2.5x more effective than a standard eczema treatment
- 85% reduction in eczema-associated Staph aureus bacteria on the skin
- 94% of participants reported reduced itching
- 100% of participants saw reduced eczema symptoms within 2 weeks
- First-of-its-kind formula breaks the cycle of itching and irritation so sensitive, eczema-prone skin can heal
- Microbiome-friendly hydrogel for eczema flare-ups on face and body
- Precision TPZ-01™ enzyme targets and kills harmful Staph aureus bacteria to rebalance the skin’s microbiome
- Lightweight cooling gel soothes and hydrates skin
- Dermatologist approved, hypoallergenic, and clinically tested for safety and efficacy
- Accepted by the National Eczema Association (NEA) and EWG Verified®
- Certified Microbiome-Friendly for Eczema for infants and adults by MyMicrobiome
- Based on a 2-week clinical trial of 24 adults with moderate to severe eczema comparing Hypothesis Eczema Precision Hydrogel to a product containing over-the-counter levels of colloidal oatmeal.
Key Ingredients
- The patented TPZ-01™ enzyme selectively targets and kills 99.99% of eczema-associated Staph aureus bacteria within 5 minutes while preserving beneficial microorganisms
- Colloidal oatmeal protects skin, soothes itching and calms irritation from eczema
- Pro-Vitamin B5 and Sorbitol are two potent moisture magnets that hydrate, comfort, and help replenish the skin barrier
- An antioxidant-rich amino acid complex helps support skin elasticity and improve moisture retention
Formulated Without
- Steroids
- Fragrance
- Silicones
- Phthalates
- Propylene glycol
- Lanolin
- Essential oils
- Dyes
Item 77005176
- Shake and apply to eczema-prone skin at least twice daily (morning and evening) or as often as desired.
- Let absorb into the skin for 5 minutes before layering on other skincare.
- Use as a standalone treatment or use in conjunction with the Hypothesis Precision Healing Spray for a double dose of the patented TPZ-01™ enzyme.
- Follow with Hypothesis Eczema Therapy Cream to lock in moisture.
- Active Ingredient: 0.01% Colloidal Oatmeal
- Inactive Ingredients: Water/Aqua/Eau, Sorbitol, Arginine HCl, Hydroxyethylpiperazine Ethane Sulfonic Acid, Panthenol, Sodium Chloride, Hydroxypropyl Methylcellulose, Methionine, Calcium Chloride, Methylparaben, Sodium Hydroxide, Acetyl Cysteine, sr-(Staphylococcus sp. Polypeptide-1 Dipeptide-81 Streptococcus Suis Phage Polypeptide-1 Dipeptide-19 Hexapeptide-40), Hydrochloric Acid
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Reviews
Write A REVIEWReview Snapshot
by PowerReviews
Ratings Distribution
52 results
Its amazing!
I use this as often as possible and the results are amazing
Preventive Maintenance
Eczema Precision Hydrogel has been a real game-changer for me, helping to cut down on the frequency of my eczema flare-ups. I've had eczema since I was a kid, and it seemed to clear up in my early to mid-twenties. But then, allergies made it come back with a vengeance! I started using this product as a proactive measure to help keep my eczema in check, instead of relying on hydrocortisone, which is my usual go-to. It's made a noticeable difference, reducing the number of times I need to use my usual method, though it doesn't quite eliminate my eczema like hydrocortisone does. The only downside is the packaging—it tends to leak everywhere. Aside from that, incorporating this into your routine between your regular treatments should show you the benefits pretty quickly.
Helped TSW Journey
Currently going through TSW and I'm sure it helped me go through the healing process a bit faster. After applying, it does sting, but it helped with the weeping which is the WORST thing. Now I only am dealing with the peeling/dryness which I'll take any day over the weeping. It doesn't help stop the itching as much as I thought it would but I'm sure that's just the process of shedding old TSW skin. I did notice a reduction in redness (red sleeves) which I was super excited about! I still have it around my wrists bc it's the hardest to heal but if I compare them to when I first started, it looks significantly better!
Great product!
This product definetely has helps my flare ups, I will say it has a strange smell to it but makes me confident that it has no added frangrances
Great for on the go barrier moisture
I had never put any kind of gel for my eczema, but I think this is a great product to use for something that is fast absorbing, but it also doesn't give you that texture sensation of having to feel product on your skin!

