Use the following zoom and pan buttons to control the image that follows them
Tab through the images or use the previous or next buttons to navigate each product image
Summary
Highlights
ma:nyo Bifida Biome Complex Ampoule fortifies the skin barrier. It visibly plumps and nourishes skin's moisture barrier for lasting hydration.
Features
- Bifida that focuses on skin nourishing, creating a balanced skin barrier and lasting hydration while improving skin tone after constant usage.
- Builds a strong foundation for the skin and protect it to make it healthy and firm
- Experience the power with healthy skin layer and strong moisture barrier to prevent future breakouts.
Key Ingredients
- Bifida Biome - Builds up the skin's barrier and keeps well-balanced skin condition.
- 10 Types of Hyaluronic Acid - Penetrates through the skin and fill in every gap between skin layers for ample hydration.
- 5 Probiotics - Strengthens the skin's barrier and helps the skin restore its original complexion.
Formulated Without
- Fragrance
- Silicon
- Paraben
Item 2626987
- Drip 3-5 drops evenly across the face, avoid the eye contour and contact with eyes.
- Lighly massage the ampoule into the skin in a circular motion.
- Finish by gently patting the skin until the essence is fully absorbed.
Bifida Ferment Lysate, Butylene Glycol, Bifida Ferment Filtrate, Lactobacillus Ferment Lysate, Lactococcus Ferment Lysate, Saccharomyces Ferment Filtrate, Glycerin, Niacinamide, 1,2-Hexanediol, Lactobacillus/Pumpkin Fruit Ferment Filtrate, Aureobasidium Pullulans Ferment, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Acetylated Hyaluronate, Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Hydrolyzed Hyaluronic Acid, Hydroxypropyltrimonium Hyaluronate, Leontopodium Alpinum Callus Culture Extract, Cutibacterium Granulosum Ferment Extract Filtrate(5,000ppm), Asiaticoside, Asiatic Acid, Madecassic Acid, Pentylene Glycol, Squalane, Hydrogenated Lecithin, Copper Tripeptide-1, Tromethamine, Acetyl Hexapeptide-8, Propanediol, Ethylhexylglycerin, Dextrin, Water, Caffeine, Benzyl Glycol, Sodium Phytate, Hydrolyzed Algin, Xanthan Gum, Epigallocatechin Gallate, Carbomer, Physalis Alkekengi Calyx Extract, Hydrolyzed Glycosaminoglycans, Polyglyceryl-10 Laurate, Theobroma Cacao (Cocoa) Seed Extract, Adenosine.
Free gift with purchase
Free gift with purchase
Online only free double cleansing set with $20 Ma:nyo purchase (valid thru 8/30/25 on in store or shipped purchases. Full or partial pickup or same day delivery purchases do not qualify. While quantities last and subject to in store availability)
We think you'll like
12 items
Use previous and next buttons to navigate the slides of the We think you'll like Product Carousel
Similar items for you
12 items
Use previous and next buttons to navigate the slides of the Similar items for you Product Carousel
Sponsored products
12 items
Use previous and next buttons to navigate the slides of the Sponsored products Product Carousel
Questions
Ask a QuestionQ&A
Showing 12 out of 12 Questions
- Q
Is this serum oil-free/noncomedogenic?
- Asked by Noncomedogenic
- Official Answer By ma:nyo - Brand EngageDear Customer, thank you for reaching out! Yes, this product is oil-free/non-comedogenic. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Can I use retinol serum and snail mucin face cream with this ampoule? If yes, before or after use this ampoule?
- Asked by Em
- Official Answer By ma:nyo - Brand EngageDear Customer, thank you for reaching out! Yes, you can use retinol serum and snail mucin face cream with the ma:nyo Bifida Biome Complex Ampoule. Generally, the ampoule should be applied before the retinol serum and after the snail mucin. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Can i use this alongside the tir tir toner or should i use one or the other?
- Asked by Hek1996
- Official Answer By ma:nyo - Brand EngageDear Customer, Yes, you can use both. Apply the TIRTIR toner first, then follow with the ma:nyo ampoule. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
What is the order of using this product with my Vitamin C serum abs also my Retinoid cream?
- Asked by DB
- Official Answer By ma:nyo - Brand EngageDear Customer, Thank you for reaching out! We recommend using your Vitamin C serum in the morning, followed by the ma:nyo Bifida Biome Complex Ampoule. In the evening, apply the ampoule before your retinoid cream. It helps to hydrate and soothe the skin, making it a great buffer between active ingredients.If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Would I use this product before or after my vit c serum in the morning?
- Asked by DBO
- Official Answer By ma:nyo - Brand EngageDear Customer, Thank you for reaching out! In the morning, apply your Vitamin C serum first, then follow with the ma:nyo Bifida Biome Complex Ampoule. This helps lock in hydration and support your skin barrier. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Can i use a vitamin C serum with this ampoule? If so, should the serum or ampoule be applied first? Can i apply one product immediately after the other, or do i need to wait for the PH to balance?
- Asked by Old
- Official Answer By ma:nyo - Brand EngageDear Customer, Thank you for reaching out! You may use a Vitamin C serum with the ma:nyo Bifida Biome Complex Ampoule. Apply the Vitamin C serum first, followed by the ampoule. There’s no need to wait between steps—both can be applied one after the other. The ampoule helps soothe and hydrate the skin, making it a great pairing with active ingredients like Vitamin C. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Do I need a toner prior to use or can I just use a moisturizer after applying this product to my skin?
- Asked by Rose
- Official Answer By ma:nyo - Brand EngageDear Customer, Thank you for reaching out! You can use ma:nyo Bifida Biome Complex Ampoule after toner. Using a toner can help prep your skin and boost absorption. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Is it safe to use in AM? It does have lactic acid in it
- Asked by N
- Official Answer By ma:nyo - Brand EngageDear Customer, Thank you for reaching out! Yes, you can safely use ma:nyo Bifida Biome Complex Ampoule in the morning. It’s gentle enough for daily use. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Can this ampule be used with the SolaWave tools- 4n1 Wand?
- Asked by Skincare Junkie
- Official Answer By ma:nyo - Brand EngageDear Customer, our ma:nyo Bifida Biome Complex Ampoule is generally safe to use with beauty devices. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Is this a good product for a open pores and oily skin?
- Asked by krishi
- Official Answer By ma:nyo - Brand EngageDear Customer, Thank you for reaching out! Yes our ma:nyo Bifida Biome Complex Ampoule is a great product for improving skin texture, strengthening the skin barrier, soothing sensitive skin, and providing deep hydration. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Is this a good product for someone with oily skin?
- Asked by mya
- Official Answer By ma:nyo - Brand EngageDear Customer, Yes, the ma:nyo Bifida Biome Complex Ampoule is suitable for oily skin. Its lightweight, watery texture absorbs quickly without leaving a greasy residue, making it ideal for layering in multi-step routines. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Can I use this before/after with retinol?
- Asked by Cat
- Official Answer By ma:nyo - Brand EngageDear Customer, Thank you for reaching out! You can use ma:nyo Bifida Biome Complex Ampoule with retinol to strengthen the skin barrier. However, since everyone's skin reacts differently, it's best to patch test first before regular use. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
Reviews
Write A REVIEWReview Snapshot
by PowerReviews
Ratings Distribution
Most Helpful Positive Review
Lightweight Hydrating Gift from God
[I received this product in exchange for my honest review] Manyo's Bifida Biome Complex Anpoule is effective, gentle skincare that targets skin barrier issues without overwhelming sensitive skin and has a probiotic-packed formula. This Korean skincare gem, priced around $24 depending on the retailer...
Most Helpful Critical Review
Healthy, Balanced, and Calm: My Experience with ma:nyo Bifid
I've been using the ma:nyo Bifida Biome Complex Ampoule consistently and it has honestly become one of my favorite steps in my skincare routine. The texture is lightweight but still feels nourishing, and it layers really well with other products without any pilling or stickiness. What I really appr...
385 results
Great K Beauty product
[I received this product in exchange for my honest review] This ampoule is a great addition to my skincare routine. The dropper is a nice way to dispense product while preventing too much bacteria from getting into bottle. The texture is a typical serum texture. I did not notice any scent. My skin felt hydrated and refreshed after use. It did not leave any sort of sticky residue after application.
Love it!
I love this product! It makes my face feel so smooth and moisturized and is great for underneath make up or as a night serum at the end of the day! The packaging is nice and the dropper is perfect for getting the right amount overall, I would recommend!
Extra hydration!
[I received this product in exchange for my honest review] My skin is aging, and every day it feels a little drier. I have improved my moisturizer, and tried a lot of options, but my skin just seems thirstier every day. I started using this product because I believe it's supposed to help your skin act more efficiently when adding moisturizer and it definitely seems to help! It's not too sticky, easy to apply, and doesn't really have a smell to it. The price is great, especially compared to some of the other items in my skin care routine! All-in-all, I'm happy I tried this and plan to continue using it!
Glass skin staple!
[I received this product in exchange for my honest review] tried the ma:nyo Bifida Biome Complex Ampoule for the first time and I'm really impressed! The texture is lightweight and absorbs quickly without leaving any stickiness. My skin immediately felt hydrated, plump, and soothed after applying it. I love that it focuses on strengthening the skin barrier because my skin tends to get easily irritated, and this gave me instant comfort. After a few uses, I noticed my skin looking more refreshed and bouncy with a healthy glow. Definitely a product I'll keep in my routine for lasting hydration and skin barrier support!
S-tier
Honestly am so grateful to have been gifted this serum because it is now an essential part of my routine and I will absolutely be purchasing it with my own money after this bottle. This stuff is incredible! I've tried what feels like hundreds of serums since i started my skincare journey years ago, but have had yet to find one worthy of becoming a staple. This serum has now officially claimed a spot in my holy grail lineup and I could not be happier. I wish I had before photos to show just how much this has improved my skin barrier over the last few weeks. My skin looks and feels healthier. It's more resilient towards otherwise irritating elements, such as accidental over-exfoliation or ingredients that my skin typically hates. I haven't experienced one breakout since incorporating this ampoule into my daily routine and all past breakouts cleared up so quickly. Even my Mom commented on how good my skin looks and this is the only new product i've been using. I could go on forever about how much i love this serum. The only thing im upset about is that I didn't give it a try sooner! Highly recommend
