Beauty in 2 hours or less—order online, pick up in store.

Use the following zoom and pan buttons to control the image that follows them

Perricone MD Neuropeptide Deep Crease Serum #1
Perricone MD Neuropeptide Deep Crease Serum #1

 Neuropeptide Deep Crease Serum

$189.00
Size:3.4 oz

Pickup and delivery options

In stock and ready to ship

Usually ships out in 1-2 days

Details

Benefits

  • This highly-potent, silky serum smooths the look of even the most stubborn, deep lines, wrinkles & creases around the mouth, eyes, lips & forehead, including marionette lines, frown lines, smile lines & nasolabial folds
  • Over time, wrinkle depth appears shallower & the look of expression lines reduced

Key Ingredients

  • Neuropeptides: Uniting Surface Cells to Fight Wrinkles
  • Biomimetic Growth Factor Peptides
  • Plant Stem Cells

Item 2648227

How To Use

After cleansing, massage onto face & neck using a gentle upward motion. Wait until fully absorbed & follow with your favorite Perricone MD moisturizer. Use morning & evening.

If the product enters the eye, rinse with water to remove.

Ingredients

Water/Aqua/Eau, Niacinamide, Coconut Alkanes, Glycerin, Caprylic/Capric Triglyceride, Isodecyl Neopentanoate, Squalane, Isononyl Isononanoate, Butylene Glycol, Lactobacillus/Glycine Soybean Ferment Extract, Polyglutamic Acid, Phenoxyethanol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Chlorella Vulgaris Extract, Glyceryl Stearate Citrate, Coco-Caprylate/Caprate, Hydroxyacetophenone, Polyglyceryl-3 Stearate, Hydrolyzed Rice Protein, Sodium Hyaluronate, Propanediol, Xanthan Gum, Pullulan, Hydrogenated Lecithin, Fragrance (Parfum), Polysorbate 60, Citric Acid, Sodium Phytate, Malus Domestica Fruit Cell Culture Extract, Sorbitan Isostearate, Glyceryl Stearate, Pentylene Glycol, Carbomer, Ceteareth-25, Coco-Glucoside, Sodium Lactate, Ubiquinone, Lecithin, Sodium Benzoate, Potassium Sorbate, Caprylyl Glycol, Acetyl Hexapeptide-8, Ceteareth-6, Lactic Acid, Pterocarpus Marsupium Bark Extract, Tocopherol, Stearyl Alcohol, Acetic Acid, Ethylhexylglycerin, Palmitoyl Tripeptide-1, Sodium Hydroxide, Palmitoyl Tetrapeptide-7, Nicotiana Benthamiana Hexapeptide-40 SH-Oligopeptide-1, Nicotiana Benthamiana Octapeptide-30 SH-Oligopeptide-2, Citronellol, Hydroxycitronellal, Limonene, Linalool.

Shipping & Coupon Restrictions

This brand is excluded from most Ulta Beauty coupons.

See brand eligibility details

Frequently bought together

3 items

Current Product

Perricone MD

 

Neuropeptide Deep Crease Serum

4.7(121)
$189.00

Make it a routine

Add these personalized recommendations to complete your beauty routine.

Step 1

Step 2

Current Product

Perricone MD

 

Neuropeptide Deep Crease Serum

4.7(121)
$189.00

Step 3

We think you'll like

12 items

Sponsored products

12 items

What do you want to know about this product?

Review Snapshot

by PowerReviews

121 ReviewsWrite a Review
Ratings Distribution
Pros
No Pros
Cons
No Cons
Most Helpful Positive Review
Botox Alternative? For SOFTENING creases trying Pe

At 42, I'm at the point where my forehead wrinkles are becoming a permanent, prominent feature, and I'm desperately trying to avoid the injectable route! I'm looking for a serious solution that can deliver noticeable results without a trip to the dermatologist, which is why I was so excited to incor...

Versus
Most Helpful Critical Review
It's ok

Been using this product for about a week--I think it could've used a longer test time and I also don't believe that a before/after photo would do the best at demonstrating its efficacy, since skincare rarely makes a dramatic enough impact to be perceptible on camera. But all the same, if that's what...

121 results

WOW!

Submitted 5 months ago

By sydneyr111_6632

From undisclosed

Verified Reviewer

Submitted as part of a sweepstakes entry

Reviewed at

Perricone MD - BV

This serum works so well. It's packed full of awesome ingredients, wears well under my other skincare and makeup, and has a smooth texture. Has a very light scent that I didn't really notice. My before and after photos are 1 week apart and you can definitely see lines smoothed and a huge improvement in texture. I definitely recommend!

Was this review helpful to you?
Good Start with Noticeable Firmness

Submitted 5 months ago

By hollyn74_8545

From undisclosed

Verified Reviewer

Submitted as part of a sweepstakes entry

Reviewed at

Perricone MD - BV

I've been using this serum for about two weeks. The texture feels silky and absorbs quickly without feeling greasy, and the scent is light and relaxing. The packaging looks simple but nice and practical. I haven't noticed much improvement in my deep wrinkles yet, but my skin does feel firmer and smoother overall. I'm hoping to see more visible results with continued use.

Was this review helpful to you?
5 star product in a 2 star package

Submitted 5 months ago

By peccadillocori_7169

From undisclosed

Verified Reviewer

Submitted as part of a sweepstakes entry

Reviewed at

Perricone MD - BV

I received this product in exchange for my honest review. I haven't left the house for a few weeks & didn't realize how bad my mustache looks but anyway… wow this product! Pros: I've only been using it for a couple of weeks & it's already taken care of my upper lip lines & I do feel like it's softening my marionette lines. It soaks into the skin so easily & is not at all irritating. Cons: The packaging is not right for this product. The glass bottle & pipette are lovely but the product is thick & the neck of the bottle is skinny. I'm not sure how much of the product you will be able to extract - which is a pity because it is really expensive. It should really be in a container like the Cold Plasma Plus Neck & Chest. The product itself is a 5* but the packaging lets it down

Was this review helpful to you?
Good

Submitted 5 months ago

By dionnem12_1333

From undisclosed

Verified Reviewer

Submitted as part of a sweepstakes entry

Reviewed at

Perricone MD - BV

Perricone MD Neuropeptide Deep Crease Serum is amazing. It smells good the texture is perfect and I like the packaging for ease of use. I would recommend.

Was this review helpful to you?
Deep treatment for aging skin

Submitted 5 months ago

By maryk337_9063

From undisclosed

Verified Reviewer

Submitted as part of a sweepstakes entry

Reviewed at

Perricone MD - BV

The serum feels smooth and oily when you put it on. It absorbs fast, though. You only need a tiny bit—a few drops go a long way. It feels very expensive, like a special treatment. I've used it for a few weeks now. I noticed my deeper lines look softer and less harsh. They aren't gone, but they look much shallower. It definitely makes a visible difference over time. It makes my skin look younger and smoother overall.

Was this review helpful to you?