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                     AM & PM  | 
                     AM & PM Followed by Moisturizer  | 
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                    Lightweight, Serum  | 
                     
                    Lightweight, Serum  | 
                     
                    Lightweight, Serum  | 
                     
                    Lightweight, Gel Serum  | 
                     
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                    Lightweight, Silky Serum  | 
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                    Cold Plasma Plus+ Advanced Hydrating Complex  | 
                     
                    High Potency Hyaluronic Moisturizer  | 
                     
                    Cold Plasma Plus+ Advanced Hydrating Complex  | 
                     
                    High Potency Retinol Recovery Overnight Moisturizer  | 
                     
                    High Potency Face Finishing & Firming Moisturizer  | 
                     
                    Cold Plasma Plus+ Advanced Hydrating Complex  | 
                     
                    High Potency Retinol Recovery Overnight Moisturizer  | 
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Summary
Perricone MD Essential Fx Acyl-Glutathione Deep Crease Serum improves the appearance of deep creases, marionette and lip lines.
Benefits
- Highly-potent serum with a silky, luxurious texture absorbs quickly to help smooth the look of even the most stubborn deep lines, wrinkles and creases around the mouth, eyes, lips and forehead, including marionette lines, frown lines, smile lines and nasolabial folds.
 - Over time, these engraved imperfections appear more shallow and the look of expression lines improve, as the vitamin F blend works to help nourish the skin’s moisture barrier and protect it from environmental aggressors.
 - 93% noticed skin looked renewed*
 - 84% saw that skin looked more toned*
 - Advanced Claims:
 - 89% noticed an improvement in lines and texture*
 - 86% felt firmer, tighter skin*
 - 86% saw an improvement in expression lines*
 - 84% saw that wrinkles were smoothed*
 - 83% noticed creases appeared shallower and forehead lines appeared smoother*
 - 82% saw tighter-looking skin*
 - 80% saw lines smoothed around the mouth and lips*
 - 79% noticed engraved imperfections appeared shallower*
 - 77% noticed that skin looked lifted*
 - 74% felt that skin looked dramatically younger*
 - 73% saw that deep-set wrinkles, including marionette lines and nasolabial folds were smoothed*
 - *In a consumer study of 102 women after 28 days
 
Key Ingredients
- Acyl-Glutathione: The Master Antioxidant
 - Vitamin F Blend: Ultimate Moisture Barrier Protection
 
Research Results
- 89% noticed an improvement in lines and fragile skin texture*
 - 86% felt firmer, tighter skin*
 - 86% saw an improvement in expression lines*
 - 84% saw wrinkles were smoothed*
 - 83% noticed creases appeared shallower and forehead lines appeared smoother*
 - *In a consumer study of 102 women after 28 days.
 
Item 2532645
After cleansing, massage onto face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer. Use morning and evening.
Water/Aqua/Eau, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Caprylic/ Capric Triglyceride, Anhydroxylitol, Phenoxyethanol, Dimethyl MEA, Lactic Acid, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylyl Glycol, Xanthan Gum, Xylitol, Caprylyl/Capryl Glucoside, Fragrance (Parfum), Linum Usitatissimum (Linseed) Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Glucose, Tetrasodium Glutamate Diacetate, Glycine Soja (Soybean) Oil, Alaria Esculenta Extract, Magnesium Aspartate, Zinc Gluconate, Sodium Hyaluronate, Ascorbyl Palmitate, Copper Gluconate, Magnesium Chloride, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Tripeptide-5, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Potassium Sorbate, Acetyl Hexapeptide-8, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Officinalis (Rosemary) Leaf Extract, Limonene, Linalool, Hydroxycitronellal, Citronellol.
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Questions
Ask a QuestionQ&A
Showing 5 out of 5 Questions
- Q
Is this good for around the eyes?
 - Asked by B
 - Official Answer By Perricone MD - Brand EngageThe Deep Crease serum was not formulate for the eye area and therefore, not tested for use around the eye area. Use would be at the user's discretion.Was this answer helpful to you
 - Q
Can you use this underneath and around your eyes
 - Asked by pj
 - Official Answer By Perricone MD - Brand EngageThe Deep Crease serum was not formulate for the eye area and therefore, not tested for use around the eye area. Use would be at the user's discretion.Was this answer helpful to you
 - Q
Does this product contain retinol
 - Asked by Laurie
 - Official Answer By PerriconeMD - SamplingHello, This is a not a retinol product. Here is the ingredient list for Deep Crease Serum. INGREDIENTS Water/Aqua/Eau, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Dimethyl MEA, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Anhydroxylitol, Lactic Acid, Xylitol, Xanthan Gum, Linum Usitatissimum (Linseed) Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Magnesium Aspartate, Zinc Gluconate, Alaria Esculenta Extract, Glucose, Sodium Hyaluronate, Copper Gluconate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Officinalis (Rosemary) Leaf Extract, Tetrasodium Glutamate Diacetate, Magnesium Chloride, Caprylic/Capric Triglyceride, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylyl/Capryl Glucoside, Caprylyl Glycol, Potassium Sorbate, Phenoxyethanol, Fragrance/Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool.Was this answer helpful to you
 - Q
Can I use with retinol cream
 - Asked by terri
 - Official Answer By PerriconeMD - SamplingYes; in fact the two will complement to a retinol cream. We suggest applying the Essential Fx Acyl-Glutathione Deep Crease Serum before our retinol treatment Firming Evening Repair for the best results.Was this answer helpful to you
 - Q
Deep smokers lines around lips. Would this product help?
 - Asked by Sandi
 - Official Answer By PerriconeMD - SamplingThis is an excellent choice of treatment for your concern.Was this answer helpful to you
 
Reviews
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Most Helpful Positive Review
I SWEAR By Deep Crease Serum!
As my title says, I SWEAR by Perricone MD's Deep Crease serum! I have been battling cancer for two years, and chemotherapy and radiation really took a toll on my skin. Although I'm 68 years young, I've always taken great care of my skin and had no wrinkles whatsoever, other than one line between my ...
Most Helpful Critical Review
Awful Fragrance
I purchased on sale recently (so I am not a receiver of a free sample). I have used for two weeks so far and cannot say I notice a difference yet in my wrinkles. What I can say is the fragrance is terrible... I am not a person who is typically bothered by fragrance/odor. I use several products wher...
13 results
Saw no visible changes after using an entire bottle
Didnt work
Oddly, ineffective
Honestly, ive been using skin care, wrinkle treatments for over 15 years, and this hasnt proven effective or given any visable signs of my smile lines improving.
Will continue to buy over and over
I took one star for the price, it is expensive, even on sale. That being said, it works. I'm 44 and after a hysterectomy forced me into menopause, my skin is not what it was even just a year ago. Fine lines and wrinkles on my forehead, bridge of my nose, and deep creasing beside my nose because I am a side sleeper. I used this product a few years ago, before menopause, just for the expression wrinkles I have on my nose and forehead, and it worked wonders. I decided to try it again and I've only been using it for a week now and I can already see a big difference. I wish I had taken pictures before, because there is definitely a BIG visible difference.
I would buy this product again
Verified Buyer
This product goes on smooth
Amazing stuff
I am 61 years old. The past 2 years I have been getting marionette lines and I developed a deep crease next to my nose, yikes! I have been saving up to see a someone about getting fillers, which is pricey and you have a to keep doing it. It has been 6 months that I have been using Perricone products. I cannot believe how much better the marionette lines look and the crease on the side of my nose is gone! I wish I had taken before and after pictures, but honestly like everything else I have tried I didn't think this would work. Finally a product that delivers what they say.