SKIP TO MAINSKIP TO FOOTER

Free standard shipping on any $35 purchase

Use the following zoom and pan buttons to control the image that follows them

Perricone MD Essential Fx Acyl-Glutathione Deep Crease Serum #1
Perricone MD Essential Fx Acyl-Glutathione Deep Crease Serum #1

Tab through the images or use the previous or next buttons to navigate each product image

Perricone MD Essential Fx Acyl-Glutathione Deep Crease Serum

Sale

sale price $92.50regularly $185.00
Size:1.0 oz

Pickup and delivery options

Unavailable to ship

Out of Stock

Earn points on this purchase.

Details

Benefits

  • Highly-potent serum with a silky, luxurious texture absorbs quickly to help smooth the look of even the most stubborn deep lines, wrinkles and creases around the mouth, eyes, lips and forehead, including marionette lines, frown lines, smile lines and nasolabial folds.
  • Over time, these engraved imperfections appear more shallow and the look of expression lines improve, as the vitamin F blend works to help nourish the skin’s moisture barrier and protect it from environmental aggressors.
  • 93% noticed skin looked renewed*
  • 84% saw that skin looked more toned*
  • Advanced Claims:
  • 89% noticed an improvement in lines and texture*
  • 86% felt firmer, tighter skin*
  • 86% saw an improvement in expression lines*
  • 84% saw that wrinkles were smoothed*
  • 83% noticed creases appeared shallower and forehead lines appeared smoother*
  • 82% saw tighter-looking skin*
  • 80% saw lines smoothed around the mouth and lips*
  • 79% noticed engraved imperfections appeared shallower*
  • 77% noticed that skin looked lifted*
  • 74% felt that skin looked dramatically younger*
  • 73% saw that deep-set wrinkles, including marionette lines and nasolabial folds were smoothed*
  • *In a consumer study of 102 women after 28 days

Key Ingredients

  • Acyl-Glutathione: The Master Antioxidant
  • Vitamin F Blend: Ultimate Moisture Barrier Protection

Research Results

  • 89% noticed an improvement in lines and fragile skin texture*
  • 86% felt firmer, tighter skin*
  • 86% saw an improvement in expression lines*
  • 84% saw wrinkles were smoothed*
  • 83% noticed creases appeared shallower and forehead lines appeared smoother*
  • *In a consumer study of 102 women after 28 days.

Item 2532645

How To Use

After cleansing, massage onto face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer. Use morning and evening.

Ingredients

Water/Aqua/Eau, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Caprylic/ Capric Triglyceride, Anhydroxylitol, Phenoxyethanol, Dimethyl MEA, Lactic Acid, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylyl Glycol, Xanthan Gum, Xylitol, Caprylyl/Capryl Glucoside, Fragrance (Parfum), Linum Usitatissimum (Linseed) Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Glucose, Tetrasodium Glutamate Diacetate, Glycine Soja (Soybean) Oil, Alaria Esculenta Extract, Magnesium Aspartate, Zinc Gluconate, Sodium Hyaluronate, Ascorbyl Palmitate, Copper Gluconate, Magnesium Chloride, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Tripeptide-5, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Potassium Sorbate, Acetyl Hexapeptide-8, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Officinalis (Rosemary) Leaf Extract, Limonene, Linalool, Hydroxycitronellal, Citronellol.

Shipping & Coupon Restrictions

This brand is excluded from most Ulta Beauty coupons.

See brand eligibility details

Make it a routine

Add these personalized recommendations to complete your beauty routine.

Step 1

La Roche-Posay

Toleriane Purifying Foaming Face Wash for Oily Skin

Size:: 13.5 oz
$21.99

Step 2

Clinique

Moisture Surge 100H Auto-Replenishing Hydrator Gel Moisturizer with Hyaluronic Acid

Size:: 4.2 oz
$88.00

Step 3

Current Product

Perricone MD

Essential Fx Acyl-Glutathione Deep Crease Serum

Sponsored products

12 items

Powered by syndigo

Find Your Best Serum

Product Comparison

This Product

Deep Crease Serum

All Skin Types

All Skin Types

All Skin Types

All Skin Types

All Skin Types

All Skin Types

All Skin Types

AM & PM

AM & PM Followed by Moisturizer

AM & PM

AM & PM

AM & PM

AM & PM

AM & PM

Deep Crease Serum Smear

Lightweight, Serum

Triple Retinol Renewal Serum Smear

Lightweight, Serum

Advanced Serum Concentrate Smear

Lightweight, Serum

Hyaluronic Intensive Hydrating Serum Smear

Lightweight, Gel Serum

Vitamin C Ester Brightening Serum Smear

Lightweight, Serum

Vitamin C Ester CCC + Ferulic Brightening Complex 20% Smear

Lightweight, Serum

Intensive Smoothing Serum Smear

Lightweight, Silky Serum

Targets:

  • Deep Wrinkles
  • Creases
  • Expression Lines
  • Crepiness
  • Loss of Smoothness


Taregts:

  • Fine Lines & Wrinkles
  • Loss of Firmness
  • Loss of Volume
  • Uneven Texture
  • Uneven Tone

Targets:

  • Fine Lines
  • Wrinkles
  • Enlarged Pores
  • Loss of Firmness
  • Redness
  • Dullness
  • Uneven Tone
  • Uneven Texture
  • Discoloration

Targets:

  • Dehydration
  • Dryness
  • Fine Lines & Wrinkles
  • Loss of Volume
  • Loss of Radiance
  • Targets:
  • Loss of Radiance
  • Redness
  • Uneven Tone
  • Targets:
  • Discoloration
  • Uneven Tone
  • Redness
  • Loss of Radiance
  • Loss of Elasticity
  • Lines & Wrinkles

Taregts:

  • Rough Texture
  • Enlarged Pores
  • Fine Lines & Wrinkles
  • Loss of Smoothness
  • Uneven Tone
  • Loss of Clarity
  • Loss of Firmness

Advanced Hydrating Complex

Cold Plasma Plus+ Advanced Hydrating Complex

High Potency Hyaluronic Intensive Mositurizer

High Potency Hyaluronic Moisturizer

Advanced Hydrating Complex

Cold Plasma Plus+ Advanced Hydrating Complex

Retinol Recovery Overnight Moisturizer

High Potency Retinol Recovery Overnight Moisturizer

High Potency Face Finishing & Firming Moisturizer

High Potency Face Finishing & Firming Moisturizer

Advanced Hydrating Complex

Cold Plasma Plus+ Advanced Hydrating Complex

Retinol Recovery Overnight Moisturizer

High Potency Retinol Recovery Overnight Moisturizer

Q&A

Showing 5 out of 5 Questions
Q
Is this good for around the eyes?
Asked by B
Official Answer By Perricone MD - Brand Engage
The Deep Crease serum was not formulate for the eye area and therefore, not tested for use around the eye area. Use would be at the user's discretion.Was this answer helpful to you
Q
Can you use this underneath and around your eyes
Asked by pj
Official Answer By Perricone MD - Brand Engage
The Deep Crease serum was not formulate for the eye area and therefore, not tested for use around the eye area. Use would be at the user's discretion.Was this answer helpful to you
Q
Does this product contain retinol
Asked by Laurie
Official Answer By PerriconeMD - Sampling
Hello, This is a not a retinol product. Here is the ingredient list for Deep Crease Serum. INGREDIENTS Water/Aqua/Eau, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Dimethyl MEA, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Anhydroxylitol, Lactic Acid, Xylitol, Xanthan Gum, Linum Usitatissimum (Linseed) Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Magnesium Aspartate, Zinc Gluconate, Alaria Esculenta Extract, Glucose, Sodium Hyaluronate, Copper Gluconate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Officinalis (Rosemary) Leaf Extract, Tetrasodium Glutamate Diacetate, Magnesium Chloride, Caprylic/Capric Triglyceride, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylyl/Capryl Glucoside, Caprylyl Glycol, Potassium Sorbate, Phenoxyethanol, Fragrance/Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool.Was this answer helpful to you
Q
Can I use with retinol cream
Asked by terri
Official Answer By PerriconeMD - Sampling
Yes; in fact the two will complement to a retinol cream. We suggest applying the Essential Fx Acyl-Glutathione Deep Crease Serum before our retinol treatment Firming Evening Repair for the best results.Was this answer helpful to you
Q
Deep smokers lines around lips. Would this product help?
Asked by Sandi
Official Answer By PerriconeMD - Sampling
This is an excellent choice of treatment for your concern.Was this answer helpful to you

Review Snapshot

by PowerReviews

13 ReviewsWrite a Review
86%
of respondents would recommend this to a friend
Ratings Distribution
Pros
Cons
Best Uses
Describe Yourself
Most Helpful Positive Review
I SWEAR By Deep Crease Serum!

As my title says, I SWEAR by Perricone MD's Deep Crease serum! I have been battling cancer for two years, and chemotherapy and radiation really took a toll on my skin. Although I'm 68 years young, I've always taken great care of my skin and had no wrinkles whatsoever, other than one line between my ...

Versus
Most Helpful Critical Review
Awful Fragrance

I purchased on sale recently (so I am not a receiver of a free sample). I have used for two weeks so far and cannot say I notice a difference yet in my wrinkles. What I can say is the fragrance is terrible... I am not a person who is typically bothered by fragrance/odor. I use several products wher...

13 results

Saw no visible changes after using an entire bottle

Submitted 4 days ago

By Rachel

From Idaho

Didnt work

Was this review helpful to you?
Oddly, ineffective

Submitted 5 months ago

By Brooke

From Florida

Honestly, ive been using skin care, wrinkle treatments for over 15 years, and this hasnt proven effective or given any visable signs of my smile lines improving.

Was this review helpful to you?
Will continue to buy over and over

Submitted 10 months ago

By Rachael

From Greenwood SC

I took one star for the price, it is expensive, even on sale. That being said, it works. I'm 44 and after a hysterectomy forced me into menopause, my skin is not what it was even just a year ago. Fine lines and wrinkles on my forehead, bridge of my nose, and deep creasing beside my nose because I am a side sleeper. I used this product a few years ago, before menopause, just for the expression wrinkles I have on my nose and forehead, and it worked wonders. I decided to try it again and I've only been using it for a week now and I can already see a big difference. I wish I had taken pictures before, because there is definitely a BIG visible difference.

Bottom Line Yes, I would recommend to a friend

Was this review helpful to you?
I would buy this product again

Submitted 3 years ago

By Wendy

From Rhode island

Verified Buyer

This product goes on smooth

Bottom Line Yes, I would recommend to a friend

Was this review helpful to you?
Amazing stuff

Submitted 4 years ago

By Maximillian98

From Texas

I am 61 years old. The past 2 years I have been getting marionette lines and I developed a deep crease next to my nose, yikes! I have been saving up to see a someone about getting fillers, which is pricey and you have a to keep doing it. It has been 6 months that I have been using Perricone products. I cannot believe how much better the marionette lines look and the crease on the side of my nose is gone! I wish I had taken before and after pictures, but honestly like everything else I have tried I didn't think this would work. Finally a product that delivers what they say.

Was this review helpful to you?