Size 1 oz|
Store & Pickup Availability
Perricone Md Essential Fx Acyl-Glutathione Deep Crease Serum is a serum to smooth deep wrinkles, creases, marionette and lip lines.
How to Use
Shipping & Coupon Restrictions
Rated 4.38 out of 5 stars
I was sent this product for free to review by perricone MD and Influenster. Although they kept telling me to review it sooner, I felt I couldn't give an honest review until I had tested it for a few weeks. I also had an issue because they forgot to send the dropper (and I didn't want to waste any!). Thankfully, Jamie at Perricone MD, was able to send me the dropper!
So here I am almost 3 weeks on and...I LOVE THIS STUFF! I won't be able to purchase once it's gone so I'm being very conservative with the application. Even with my light use, I've had amazing results!
After 1 use only, I can feel the difference in my skin. My skin felt very moisturized (you follow with your moisturizer which I felt absorbed better after this product) and was velvety soft.
On my third day of using this product, my friend actually complimented me on how I looked. She knew something was different but assumed I was wearing makeup when I wasn't! That's the biggest tell that a product is working IMHO, when others notice a difference.
I have a rare disorder that causes heavy sweating, which causes dehydration, which causes your skin to age faster. I also HAD (cured!!!) ovarian cancer which aged me 10 years so I really appreciate #infuenster and #perriconemd sending this to me for free to review. I'm living in poverty because of my illness and wouldn't have been able to try this product otherwise.
I truly believe this serum is something special! I love everything about it right down to the light rose scent. I will be truly sad when it's gone because of the amount of difference it's made in my appearance. Thank you, Perricone MD, thank you!
I received this sample for free from Influenster. I have only used the product for about a week which I do not feel is enough time for an informed opinion but they keep insisting that I review it already so here goes. The serum made my skin feel nice and smooth and gave me a glow immediately on application. I do feel that the appearance of my lines is softened but for a product that costs this much I expected more. I get similar results from my natural face oil that I have been using for years. My bottle had no dropper and was just a twist off top which makes application a hassle. Is this how the product is sold or was this just for the sample? It is cumbersome and wasteful to have to pour out the product onto my hand to use. I am also very wary of the nanotechnology that is being used in the product. Studies have shown that these chemicals are made so small with this technology that they are absorbing into our bodies and their long term effects are not known at this time. Studies have also shown that these products have been found to build up in ones system over time and have been found inside tumors among other things. I will not purchase this product in the future. Between the exhorbitant price and the possible health risk it is not worth it to me.
Maximillian98 from Texas
I am 61 years old. The past 2 years I have been getting marionette lines and I developed a deep crease next to my nose, yikes! I have been saving up to see a someone about getting fillers, which is pricey and you have a to keep doing it. It has been 6 months that I have been using Perricone products. I cannot believe how much better the marionette lines look and the crease on the side of my nose is gone! I wish I had taken before and after pictures, but honestly like everything else I have tried I didn't think this would work. Finally a product that delivers what they say.
saramt from Dayton, OH
LOVE this stuff! I started seeing results within three days of use. I'm 37 and developed deep '11' lines on my forehead, thanks 2020, and this smoothed them to almost nonexistence. Worth the price to me, much cheaper than injectables.
Rosierose24 from Las Vegas
This serum is good for deep creases. I can tell a difference when I use it.
Ceegee from Louisiana
Taking advantage of the great deals that occur on this website, I have a variety of the serums, Sub D, moisturizers and use them in different combinations. At 68, I'm loving my skin. When I added the Deep Crease Serum to the areas in need, I really saw a marked improvement. Auto Replenishment, check!
Swan from Los Angeles, CA
I'm not sure why, but I don't get any kind of results from this product. For reference, I'm 46 and tried this on a chest crease, deep and light wrinkles on my neck, and even on tiny tiny wrinkles on my forehead, but no result anywhere. I put this on fresh clean skin, first thing in the morning, before going to bed, and also during the day. I've almost used the entire bottle, and I've been using it diligently for a few months. However, I will mention that I love Perricone facial moisturizer and will probably never use anything else!
Chase from Georgia
Use this product regularly and bought on sale. Feel like it makes a difference on sleep lines. 4 stars because of price (even though I bought on sale).
Nika from Oakland Ca
So this is my first time trying the deep crease serum but love the sub d products hands down ! But, this product is well worth the extra coin instead of injections or boxtox! I promise! Put it definitely in the creasing area of your neck and just like that they're gone! One day!!! Take a picture if you don't believe me! I'm 45 by the way so I have that creasing in the area where you look down alot and just naturally aging area of the nexk and laugh lines , "What laugh lines?!" Plumped up honey! Im sold! And will scrape every penny to stay with this in my cabinet as long as I live!! Thanks Dr Perricone! You're the best!
Gloria from Undisclosed
I have been using the Deep Crease Serum for about 4 years alone with the High Potency Amine Face Lift, Cold Plasma Sub-D. I am a 73 year old lady that love love these products. I can really tell the difference in my skin since I started using 4 years ago.
Colleen from St. Louis
this product deserves 5 stars, but I can't bring myself to do it. This product is so expensive, but the eyedrop stops working after a while and with a glass container, you can't get it all out. I fell like a good part of my money is wasted.
J. K. from USA
This is a great product, you can see a noticeable difference in deep wrinkles with use. I buy it for my Mother in law. Every Christmas and mother's day. I got it for her for mother's day one year, and she asked for more for Christmas, and now it's the only gift she wants. She loves it! She says it keeps her young, she's in her late 60s. I just wish it wasn't so expensive for such a small bottle!
Marie from Anchorage
I used this product for a couple years and really liked it. However, the most recent version that I purchased is now heavily perfumed. It is now is a white lotion instead of a clear serum. I cannot use products with fragrance on my face, especially ones with this strong a scent (although it is not an unpleasant scent). Therefore unfortunately I can no longer recommend this serum.
Poodie from Huntsville, AL
I use this product over face and neck every morning. It goes on very smoothly, evens out the creases in and around my chin, and visibly improves the look of my skin. I have used Perricone products since 2003. I am 70 years of age and no one ever guesses anywhere close. My thanks to NV Perricone!
Jagdiva from Dallas GA
I had used Dr Perricone's product line many years ago and found it beneficial, so when I had tried various brands ($ to $$$) with no noticeable improvement, I decided to go back and see what products he had that could improve my wrinkles on forehead and around mouth/chin area. I received this product about a week ago, have been using twice a day. It may be too early to tell, but it looks promising that improvement is happening..
Law from CA-California
It is probably too soon to say, as I have not noticed any difference yet.
CW from Mass
Just finished the bottle and have seen no change at all
Marie from Chicago, IL
I noticed a difference immediately after using this. Tried it for the first time about a year ago, stopped using it for a while, and restarted just recently. It seems to "pick up" my entire face. Definitely, try this.
Anne of Texas from Texas
I got samples of this with purchase of another product and I have been using it on the lines around my lips and can already see a difference. It is an expensive product but if you can afford it and have lines around your lips this is certainly the serum to try.
Cary from Los Angeles
Mosterizes. Fast results.
LT from Michigan
I typically use three drops of this, one on each cheek and one on my forehead. It makes my skin look moist and healthier _ more so than any other product I've ever used. I fell in love with it for that reason before I even realized that it helps with wrinkles!
Sandy from Honolulu
The best serum that I've ever purchased. I use it under my moisturizer and it delivers all day!
Pilates Patty from Long Beach, CA
Seems to be drying
Mike C. from Los Angeles
Most importantly, this product seems to be working well. I don't love the bottle as packaging or the dropper. The consistency of the product makes it difficult to get out of the bottle, with or without the dropper.
Sherrie from Bellingham, WA
I have been using this product religiously for around a month and a half now and have seen zero improvement. I wish I had kept the packaging so I could return it. I do not recommend.
Kristaashley from San Diego, California
I used twice a day and as directed. This serum did nothing. I had better luck with a hyaluronic serum that was a fraction of the price.
The Hiker from Massachusetts
Since it is a deep crease serum, I expected to see results after 7-10 days, as with most Perricone products. I've been using this product for two weeks, morning and night, and barely notice any improvement. I've been very happy with other Perricone products over the years but very surprised with this product. Maybe more time is required before results are achieved.
My concern area is the smile lines around the mouth, beginning at the corner or nose down to mouth on each side. My eleven (two lines between the eyes) is minimized with this product.