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Highlights
Summary
Clinique Smart Night Clinical MD Treatment Retinol Serum is a skin-repairing night treatment that jumpstarts the anti-aging process with retinol plus hydration.
Benefits
- All Skin Types.
- Powered by 0.3% retinol, this creamy formula sinks in to help speed up cell turnover.
- Visibly reduces fine lines and wrinkles.
- Skin tone looks more even, radiant.
- Pores look minimized.
- Delivers instant and lasting hydration, which helps comfort skin and offset dryness sometimes associated with retinol.*
- *Tolerance to retinol varies by person.
- What you should know about retinol:
- Retinol is an extremely effective and powerful anti-aging ingredient. You may experience mild redness, a warm, tingling sensation, or flaking (skin exfoliation). These conditions are normal, temporary indications that the formula is working.
- If you experience increased discomfort when using this product, revert to once every other night until skin adjusts. This adjustment can take up to 4 weeks.
- First time users and those with drier skin types may want to use this product every other night for more than 2 weeks to give skin additional time to adjust.
- For added comfort, use a mild cleanser and layer an additional moisturizer over this product.
- Limit sun exposure in general. Be sure to apply a sunscreen of SPF15 or higher during the day while using this product, and one week after stopping use of it. Note that extreme weather conditions such as wind or cold may be more irritating, so take the proper precautions to protect your face.
- Paraben-free. Phthalate-free.
- No Denatured alcohol. No Synthetic colors.
- SLS-free. SLES-free. Sulfate-free.
- Dermatologist tested.
- Allergy tested. Fragrance-free.
Key Ingredients
- Retinol (0.3%): A pure form of Vitamin A, it's an effective anti-aging ingredient known to help visibly reduce lines and wrinkles, minimize the appearance of pores, and smooth and refine texture.
- Youth-Boosting Blend: Helps skin look smoother. Includes acetyl hexapeptide-8, niacinamide, sigesbeckia extract, and ascorbic acid.
- Comforting Hydrator Blend: Helps infuse skin with hydration. Includes hyaluronic acid, mango seed butter, wheat and barley extract, coffee seed oil, squalane, and vitamin E.
Research Results
- Clinical Testing:
- Restores radiance with 1 use.
- Minimizes the appearance of pores in 7 days.
- Skin feels smoother in 28 days/4 weeks.
- Improves evenness of skin tone in 8 weeks.
- Retexturizes skin in 12 weeks.
- Provides instant and lasting hydration.
- With continued use, visibly reduces lines and wrinkles.
Item 2572793
Apply pea size amount (0.25g) of retinol at night. Avoid eye area. Tip: For first two weeks, use every other night, then nightly. Use sunscreen and limit sun exposure while using and the week after. Do not use with other retinol products, such as Clinique Fresh Pressed Overnight Booster with Pure Vitamin A (Retinol).
To help optimize the results of retinol, we suggest using as part of a regimen with other anti-aging products, such as:
- In AM: Clinique Smart Custom-Repair Serum + Clinique Smart SPF 15 Custom-Repair Moisturizer
- In PM: Clinique Smart Custom-Repair Serum + Clinique Smart Night Retinol + Clinique Smart Clinical MD Resculpt or Revolumize or Clinique Smart Night Custom-Repair Moisturizer (for added comfort if needed).
Water\Aqua\Eau, Caprylic/Capric Triglyceride, PPG-15 Stearyl Ether, C12-20 Acid PEG-8 Ester, Glycerin, Niacinamide, Phenyl Trimethicone, Caprylic/Capric/Myristic/Stearic Triglyceride, Algae Extract, Dimethicone, Hydroxyethyl Urea, Cetyl Alcohol, Retinol, Sigesbeckia Orientalis (St. Paul'S Wort) Extract, Mangifera Indica (Mango) Seed Butter, Coffea Arabica (Coffee) Seed Oil, Sodium Hyaluronate, Caffeine, Ascorbic Acid, Urea, Butylene Glycol, Squalane, Trehalose, Triticum Vulgare (Wheat) Germ Extract, Tocopheryl Acetate, PEG-100 Stearate, Linoleic Acid, Glyceryl Stearate, Hordeum Vulgare (Barley) Extract\Extrait D'Orge, Acetyl Hexapeptide-8, Sorbitol, Potassium Cetyl Phosphate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tocopherol, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Behenyl Alcohol, Sodium Pca, Sodium Hydroxide, Caprylyl Glycol, Carbomer, Triacetin, Polyquaternium-51, Xanthan Gum, BHT, Disodium EDTA, Sodium Metabisulfite, Chlorphenesin, Potassium Sorbate, Phenoxyethanol.
Please be aware that ingredient lists may change or vary from time to time. Please refer to the ingredient list on the product package you receive for the most up to date list of ingredients.
This brand is excluded from most Ulta Beauty coupons.
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Questions
Ask a QuestionQ&A
Showing 5 out of 10 Questions
- Q
What percent is this product
- Asked by Mary
- Official Answer By Clinique USWe're glad you asked! Clinique Smart Night Clinical MD Multi-Dimensional Repair Treatment Retinol, which contains Retinol (0.3%), a pure form of Vitamin A as an effective anti-aging ingredient known to help visibly reduce lines and wrinkles, minimize the appearance of pores, and smooth and refine texture. Retinol is an extremely effective and powerful anti-aging ingredient. We do not recommend using two retinol products together. Be sure you are limiting sun exposure while using, and for at least one week after. Visit our store, and a Beauty Associate will offer personalized application tips. We'd love to hear your feedback!Was this answer helpful to you
- Q
Do you have a night cream moisturizer
- Asked by T
- Official Answer By Clinique USWe are so happy you asked! We have a great moisturizer for nighttime use that works perfectly with this serum. Clinique's Smart Clinical Repair Wrinkle Correcting Cream visibly repairs lines and wrinkles, hydrates and strengthens. Visit us in-store at your nearest Ulta to experience this moisturizer!Was this answer helpful to you
- Q
You recommend using clinique smart night moisturizer after using this product, however that is no longer available on your website. Will you be bringing this back? I was told to use this in place of the moisturizer at night. This is frustrating.
- Asked by Patty
- Official Answer By Clinique USThanks for asking, we never want our fans frustrated! Clinique Smart Night Clinical MD Multi-Dimensional Repair Treatment Retinol Serum, as a serum, should be followed by your favorite Clinique moisturizer after. We like Clinique Smart Clinical Repair Wrinkle Correcting Cream (or Rich Cream for those that need deep hydration). This moisturizer may be used in place of the retired Clinique Smart Night Custom-Repair Moisturizer. When using the serum, for the first two weeks, only use it every other night, then nightly. Remember to always use sunscreen and limit sun exposure while using and the week after.Was this answer helpful to you
- Q
Do I moisturize before or after?
- Asked by donkey mom
- Official Answer By Clinique USWe're so glad you asked! Apply your moisturizer after Clinique Smart Night Clinical MD Multidimensional Repair Treatment Retinol. We recommend Clinique Smart Clinical MD Multi-Dimensional Age Transformer Resculpt or Revolumize or Clinique Smart Night Custom-Repair Moisturizer. Enjoy!Was this answer helpful to you
- Q
Can I use this with the night time turn around cream?
- Asked by Laura
- Official Answer By Clinique USThank you for your question. We recommend using Clinique Smart Nigth Clinical MD Multi-Dimensional Repair Treatment Retinol with Clinique Smart Night Custom-Repair Moisturizer, which helps skin attract and retain moisture and gives skin an extra boost of repair while you sleep. We can't wait to hear what you think! Was this answer helpful to you
Reviews
Write A REVIEWReview Snapshot
by PowerReviews
Ratings Distribution
Skin Type
Most Helpful Positive Review
Excellent!
The negative reviews of this product surprise me and that some are saying that the directions are not clear. Any time one uses a Retinol product, you HAVE to apply a moisturizer over it. If you don't, you will end up with red, dry, painful skin. The directions on the pkg insert as well as here under...
Most Helpful Critical Review
Too intense for my dry and sensitive skin
I used this product as directed and had to discontinue it before I even made it out of the two week period where you only use it every other day. As a disclaimer I wasn't even going outside (thanks COVID) so it wasn't like I got a bunch of sun and messed myself up. I really did use it as directed. ...
114 results
Beware of this product!
Verified Reviewer
Reviewed at

I'm 63 and this product was recommended by an Ulta clerk after the Smart night moisturizer was discontinued. My face became red like a sun burn, the texture was like an alligator and then it started to peel off and flake terribly. I would caution those of you with sensitive skin not to use this product. I have used Clinique for years and will continue to do so, but I feel the store clerks should inform customers of the adverse effects.
Start slow
This retinol is nice but start slow. I thought my skin was ready for this but nope. I got very sensitive around the eyes after the first use. But it works wonders on acne around my chin and jaw. Also use it on my neck and lessened the wrinkles
Great Retinol Product/ Really Impressed
Verified Reviewer
Reviewed at

I am 42 yrs old, combination dry skin, few laugh lines (and side of eyes) and dark circles. I recently started researching retinol to add to my skincare routine. (I first started with a store bought brand that was too strong and made my face red). I wanted something with Retinol and Hyaluronic Acid. (Which I now see a lot of Clinique products have the Hyaluronic Acic for moisture. And carry retinol stuff and I never noticed. Ha! ) So, I search the website and accidentally ordered this Night clinical MD multi-dimensional Repair instead of the Smart Repair Wrinkle Correcting Serum. So I gave this a try anyway. And I MUST SAY, I was really impressed! IT HAS DONE Wonderfully on my skin in just a couple weeks. My skin is softer, Looks fresher, and I don't even wear as much make up. I also use Smart Clinical Repair Wrinkle Eye Cream, and The Moisture Surge cream twice a day and Clinique Smart Night Custom-Repair Moisturizer sometimes at night. I do need to find a better SPF to use when I start going outside more. Hope these results will continue.
I like it very much.
Verified Reviewer
Reviewed at

My skin is getting brighter and smoother and works very well for my sensitive skin.
Works, but have to be gentle
Verified Reviewer
Reviewed at

It does make a difference to the way my skin looks. It's a bit drying and irritating for sensitive skin so cannot use it everyday. On the packaging it says after the initial week can use eveyrdya night? But i use it eveyrday 2-3 days and think it's great.