Use the following zoom and pan buttons to control the image that follows them
Tab through the images or use the previous or next buttons to navigate each product image
Earn points on this purchase.
Highlights
Summary
ma:nyo Bifida Biome Complex Ampoule fortifies the skin barrier. It visibly plumps and nourishes skin's moisture barrier for lasting hydration.
Features
- Bifida that focuses on skin nourishing, creating a balanced skin barrier and lasting hydration while improving skin tone after constant usage.
- Builds a strong foundation for the skin and protect it to make it healthy and firm
- Experience the power with healthy skin layer and strong moisture barrier to prevent future breakouts.
Key Ingredients
- Bifida Biome - Builds up the skin's barrier and keeps well-balanced skin condition.
- 10 Types of Hyaluronic Acid - Penetrates through the skin and fill in every gap between skin layers for ample hydration.
- 5 Probiotics - Strengthens the skin's barrier and helps the skin restore its original complexion.
Formulated Without
- Fragrance
- Silicon
- Paraben
Item 2626987
- Drip 3-5 drops evenly across the face, avoid the eye contour and contact with eyes.
- Lighly massage the ampoule into the skin in a circular motion.
- Finish by gently patting the skin until the essence is fully absorbed.
Bifida Ferment Lysate, Butylene Glycol, Bifida Ferment Filtrate, Lactobacillus Ferment Lysate, Lactococcus Ferment Lysate, Saccharomyces Ferment Filtrate, Glycerin, Niacinamide, 1,2-Hexanediol, Lactobacillus/Pumpkin Fruit Ferment Filtrate, Aureobasidium Pullulans Ferment, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Acetylated Hyaluronate, Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Hydrolyzed Hyaluronic Acid, Hydroxypropyltrimonium Hyaluronate, Leontopodium Alpinum Callus Culture Extract, Cutibacterium Granulosum Ferment Extract Filtrate(5,000ppm), Asiaticoside, Asiatic Acid, Madecassic Acid, Pentylene Glycol, Squalane, Hydrogenated Lecithin, Copper Tripeptide-1, Tromethamine, Acetyl Hexapeptide-8, Propanediol, Ethylhexylglycerin, Dextrin, Water, Caffeine, Benzyl Glycol, Sodium Phytate, Hydrolyzed Algin, Xanthan Gum, Epigallocatechin Gallate, Carbomer, Physalis Alkekengi Calyx Extract, Hydrolyzed Glycosaminoglycans, Polyglyceryl-10 Laurate, Theobroma Cacao (Cocoa) Seed Extract, Adenosine.
We think you'll like
12 items
Use previous and next buttons to navigate the slides of the We think you'll like Product Carousel
Similar items for you
12 items
Use previous and next buttons to navigate the slides of the Similar items for you Product Carousel
Sponsored products
12 items
Use previous and next buttons to navigate the slides of the Sponsored products Product Carousel
Questions
Ask a QuestionQ&A
Showing 17 out of 12 Questions
- Q
Is this serum oil-free/noncomedogenic?
- Asked by Noncomedogenic
- Official Answer By ma:nyo - Brand EngageDear Customer, thank you for reaching out! Yes, this product is oil-free/non-comedogenic. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Can I use retinol serum and snail mucin face cream with this ampoule? If yes, before or after use this ampoule?
- Asked by Em
- Official Answer By ma:nyo - Brand EngageDear Customer, thank you for reaching out! Yes, you can use retinol serum and snail mucin face cream with the ma:nyo Bifida Biome Complex Ampoule. Generally, the ampoule should be applied before the retinol serum and after the snail mucin. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Can i use this alongside the tir tir toner or should i use one or the other?
- Asked by Hek1996
- Official Answer By ma:nyo - Brand EngageDear Customer, Yes, you can use both. Apply the TIRTIR toner first, then follow with the ma:nyo ampoule. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
What is the order of using this product with my Vitamin C serum abs also my Retinoid cream?
- Asked by DB
- Official Answer By ma:nyo - Brand EngageDear Customer, Thank you for reaching out! We recommend using your Vitamin C serum in the morning, followed by the ma:nyo Bifida Biome Complex Ampoule. In the evening, apply the ampoule before your retinoid cream. It helps to hydrate and soothe the skin, making it a great buffer between active ingredients.If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Would I use this product before or after my vit c serum in the morning?
- Asked by DBO
- Official Answer By ma:nyo - Brand EngageDear Customer, Thank you for reaching out! In the morning, apply your Vitamin C serum first, then follow with the ma:nyo Bifida Biome Complex Ampoule. This helps lock in hydration and support your skin barrier. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Can i use a vitamin C serum with this ampoule? If so, should the serum or ampoule be applied first? Can i apply one product immediately after the other, or do i need to wait for the PH to balance?
- Asked by Old
- Official Answer By ma:nyo - Brand EngageDear Customer, Thank you for reaching out! You may use a Vitamin C serum with the ma:nyo Bifida Biome Complex Ampoule. Apply the Vitamin C serum first, followed by the ampoule. There’s no need to wait between steps—both can be applied one after the other. The ampoule helps soothe and hydrate the skin, making it a great pairing with active ingredients like Vitamin C. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Do I need a toner prior to use or can I just use a moisturizer after applying this product to my skin?
- Asked by Rose
- Official Answer By ma:nyo - Brand EngageDear Customer, Thank you for reaching out! You can use ma:nyo Bifida Biome Complex Ampoule after toner. Using a toner can help prep your skin and boost absorption. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Is it safe to use in AM? It does have lactic acid in it
- Asked by N
- Official Answer By ma:nyo - Brand EngageDear Customer, Thank you for reaching out! Yes, you can safely use ma:nyo Bifida Biome Complex Ampoule in the morning. It’s gentle enough for daily use. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Can this ampule be used with the SolaWave tools- 4n1 Wand?
- Asked by Skincare Junkie
- Official Answer By ma:nyo - Brand EngageDear Customer, our ma:nyo Bifida Biome Complex Ampoule is generally safe to use with beauty devices. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Is this a good product for a open pores and oily skin?
- Asked by krishi
- Official Answer By ma:nyo - Brand EngageDear Customer, Thank you for reaching out! Yes our ma:nyo Bifida Biome Complex Ampoule is a great product for improving skin texture, strengthening the skin barrier, soothing sensitive skin, and providing deep hydration. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Can i use a vitamin C serum with this ampoule? If so, should the serum or ampoule be applied first? Can i apply one product immediately after the other, or do i need to wait for the PH to balance?
- Asked by Old
- Official Answer By ma:nyo - Brand EngageDear Customer, Thank you for reaching out! You may use a Vitamin C serum with the ma:nyo Bifida Biome Complex Ampoule. Apply the Vitamin C serum first, followed by the ampoule. There’s no need to wait between steps—both can be applied one after the other. The ampoule helps soothe and hydrate the skin, making it a great pairing with active ingredients like Vitamin C. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Do I need a toner prior to use or can I just use a moisturizer after applying this product to my skin?
- Asked by Rose
- Official Answer By ma:nyo - Brand EngageDear Customer, Thank you for reaching out! You can use ma:nyo Bifida Biome Complex Ampoule after toner. Using a toner can help prep your skin and boost absorption. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Is it safe to use in AM? It does have lactic acid in it
- Asked by N
- Official Answer By ma:nyo - Brand EngageDear Customer, Thank you for reaching out! Yes, you can safely use ma:nyo Bifida Biome Complex Ampoule in the morning. It’s gentle enough for daily use. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Can this ampule be used with the SolaWave tools- 4n1 Wand?
- Asked by Skincare Junkie
- Official Answer By ma:nyo - Brand EngageDear Customer, our ma:nyo Bifida Biome Complex Ampoule is generally safe to use with beauty devices. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Is this a good product for a open pores and oily skin?
- Asked by krishi
- Official Answer By ma:nyo - Brand EngageDear Customer, Thank you for reaching out! Yes our ma:nyo Bifida Biome Complex Ampoule is a great product for improving skin texture, strengthening the skin barrier, soothing sensitive skin, and providing deep hydration. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Is this a good product for someone with oily skin?
- Asked by mya
- Official Answer By ma:nyo - Brand EngageDear Customer, Yes, the ma:nyo Bifida Biome Complex Ampoule is suitable for oily skin. Its lightweight, watery texture absorbs quickly without leaving a greasy residue, making it ideal for layering in multi-step routines. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
- Q
Can I use this before/after with retinol?
- Asked by Cat
- Official Answer By ma:nyo - Brand EngageDear Customer, Thank you for reaching out! You can use ma:nyo Bifida Biome Complex Ampoule with retinol to strengthen the skin barrier. However, since everyone's skin reacts differently, it's best to patch test first before regular use. If you have any other questions, feel free to ask—we’re always happy to help!Was this answer helpful to you
Reviews
Write A REVIEWReview Snapshot
by PowerReviews
Ratings Distribution
Most Helpful Positive Review
Lightweight Hydrating Gift from God
[I received this product in exchange for my honest review] Manyo's Bifida Biome Complex Anpoule is effective, gentle skincare that targets skin barrier issues without overwhelming sensitive skin and has a probiotic-packed formula. This Korean skincare gem, priced around $24 depending on the retailer...
Most Helpful Critical Review
Healthy, Balanced, and Calm: My Experience with ma:nyo Bifid
I've been using the ma:nyo Bifida Biome Complex Ampoule consistently and it has honestly become one of my favorite steps in my skincare routine. The texture is lightweight but still feels nourishing, and it layers really well with other products without any pilling or stickiness. What I really appr...
440 results
Great Basic serum
[I received this product in exchange for my honest review] I've been using the Manyo Bifida Biome Complex Ampoule once a day for about a month now, so I feel like I've gotten a good sense of what it does and doesn't do for my skin. Here are a few things that I liked: The texture is lightweight, absorbs pretty quickly, and doesn't make my skin feel sticky or heavy. It helps with hydration. After especially drying days or harsh cleansers, this ampoule soothes and brings back some plumpness without any irritation. I appreciate that there's a fair amount of product and the bottle seems like it'll last a while, even with regular use. It's gentle enough that I didn't have any breakouts or issues from it, even when layering with other products that I use at night. Some of the things I didn't love and what I wish were different: Despite the hydration, I'm not seeing any dramatic changes like brighter skin tone or fading of spots, or redness yet. My skin texture is a bit smoother, but nothing super noticeable in photos or in the mirror from a distance. The fine lines and firmness claims may need more time for it to be evident but I'm not convinced there's a firming effect yet. For the amount I'd be paying which is a fairly decent price, I expected a bit more of a wow factor or more of a glow. It's solid, but doesn't feel like a game-changer at this point. The bottom line is this ampoule is a good product especially if you want a gentle hydrator and skin-barrier support serum. If you're looking for big brightness or anti‑aging results fast, you may need to combine it with other targeted treatments or give it more time. Overall, I'll probably repurchase, because it does the basics of what it promises.

Love this product
[I received this product in exchange for my honest review] There is no scent which I like, it feels thick when it goes on but doesn't leave any shine and feels really light on your face. The packaging is really cool and innovative.
Korean skin
Feel good on skin
My new favorite product
[I received this product in exchange for my honest review] This product is EVERYTHING! No strong overwhelming scent, very light and absorbs into the skin well. Very light weight , no oily after feeling. The packaging is very simple. Must have for your skin care routine.
Great great great
This serum nourishes and moisturizes my skin so well. I have sensitive skin and it leaves me feeling so soft without a tacky residue feeling. Layers really well under my sunscreen and doesn't pill. Another plus is the affordability for the quality. I've tried many others at various price points and this one does not disappoint.